Dasatinib Inhibits FLT3/ITD and PTPN11mutated Acute Myeloid Leukemia Cells Overexpressing SRC Tyrosine Kinases

被引：0
|
作者：
Tavor, Sigal [1 ]
Shalit, Tali [2 ]
Ilani, Noa Chapal [3 ]
Moskovitz, Yoni [3 ]
Livnat, Nir [2 ]
Groner, Yoram [2 ]
Bar, Haim [2 ]
Plotnikov, Alexander [2 ]
Kaushansky, Nathali [3 ]
Shlush, Liran I. [3 ]
机构：
[1] Assuta Med Ctr, Hematooncol, Tel Aviv, Israel
[2] Weizmann Inst Sci, Rehovot, Israel
[3] Weizmann Inst Sci, Dept Immunol, Rehovot, Israel
来源：
BLOOD | 2019年 / 134卷
关键词：
D O I：
10.1182/blood-2019-128016
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1451
引用
收藏
页数：4
相关论文
共 50 条
  • [31] Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia
    He, Bai-Liang
    Yang, Ning
    Man, Cheuk Him
    Ng, Nelson Ka-Lam
    Cher, Chae-Yin
    Leung, Ho-Ching
    Kan, Leo Lai-Hok
    Cheng, Bowie Yik-Ling
    Lam, Stephen Sze-Yuen
    Wang, Michelle Lu-Lu
    Zhang, Chun-Xiao
    Kwok, Hin
    Cheng, Grace
    Sharma, Rakesh
    Ma, Alvin Chun-Hang
    So, Chi-Wai Eric
    Kwong, Yok-Lam
    Leung, Anskar Yu-Hung
    EMBO MOLECULAR MEDICINE, 2020, 12 (04)
  • [32] Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia
    Williams, Allen B.
    Li, Li
    Bao Nguyen
    Brown, Patrick
    Levis, Mark
    Small, Donald
    BLOOD, 2012, 120 (15) : 3069 - 3079
  • [33] Detection of FLT3/ITD mutations in adult patients with acute myeloid leukemia in the Mongolia
    Oyunbileg, S.
    Batbayar, D.
    Batsukh, K.
    Norov, O.
    Enebish, O.
    Baatar, N.
    Baasanjav, S.
    ONCOLOGY RESEARCH AND TREATMENT, 2018, 41 : 54 - 54
  • [34] The FLT3 tyrosine kinase receptor ITD mutation controls its expression and drug resistance in acute myeloid leukemia
    Alqahtani, Taha
    MacEwan, David
    CANCER RESEARCH, 2024, 84 (06)
  • [35] A Novel Combination Regimen of BET and FLT3 Inhibition for FLT3-ITD Acute Myeloid Leukemia
    Lee, Lauren
    Hizukuri, Yoshiyuki
    Severson, Paul
    Powell, Ben
    Zhang, Chao
    Ma, Yan
    Narahara, Maiko
    Sumi, Hiroyuki
    Bollag, Gideon
    Levis, Mark J.
    BLOOD, 2019, 134
  • [36] A novel combination regimen of BET and FLT3 inhibition for FLT3-ITD acute myeloid leukemia
    Lee, Lauren
    Hizukuri, Yoshiyuki
    Severson, Paul
    Powell, Benjamin
    Zhang, Chao
    Ma, Yan
    Narahara, Maiko
    Sumi, Hiroyuki
    Hernandez, Daniela
    Rajkhowa, Trivikram
    Bollag, Gideon
    Levis, Mark
    HAEMATOLOGICA, 2021, 106 (04) : 1022 - 1033
  • [37] More on prognostic significance of FLT3/ITD size in acute myeloid leukemia (AML)
    Kusec, Rajko
    Jaksic, Ozren
    Ostojic, Slobodanka
    Kardum-Skelin, Ika
    Vrhovac, Radovan
    Jaksic, Branimir
    BLOOD, 2006, 108 (01) : 405 - 406
  • [38] Effects of the Flt3 ITD on response to chemotherapy in a murine model of acute myeloid leukemia
    Pardee, T. S.
    Zuber, J.
    Lowe, S. W.
    JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)
  • [39] Characterization of acute myeloid leukemia with PTPN11 mutation:: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD
    Hou, H-A
    Chou, W-C
    Lin, L-I
    Chen, C-Y
    Tang, J-L
    Tseng, M-H
    Huang, C-F
    Chiou, R-J
    Lee, F-Y
    Liu, M-C
    Tien, H-F
    LEUKEMIA, 2008, 22 (05) : 1075 - 1078
  • [40] Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD
    H-A Hou
    W-C Chou
    L-I Lin
    C-Y Chen
    J-L Tang
    M-H Tseng
    C-F Huang
    R-J Chiou
    F-Y Lee
    M-C Liu
    H-F Tien
    Leukemia, 2008, 22 : 1075 - 1078
12345