OTS167 Inhibits FLT3 Expression in FLT3 Mutant Acute Myeloid Leukemia

被引:0
|
作者
Eisfelder, Bartholomew [1 ]
Wynne, Joseph [1 ]
Colton, Margert [1 ]
Cheng, Jason [2 ]
Odenike, Olatoyosi [1 ]
Alachkar, Houda [3 ]
Stock, Wendy [1 ]
机构
[1] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Pathol, Hematopathol Sect, 5841 S Maryland Ave, Chicago, IL 60637 USA
[3] Univ Southern Calif, Sch Pharm, Dept Clin Pharm & Pharmaceut Econ & Policy, Los Angeles, CA USA
来源
关键词
FLT3; FLT3-ITD; MELK; OTS167; eIF4B; AML; acute myeloid leukemia;
D O I
10.1016/j.clml.2019.07.133
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
AML-388
引用
收藏
页码:S239 / S240
页数:2
相关论文
共 50 条
  • [1] OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia
    Bartholomew J. Eisfelder
    Caner Saygin
    Joseph Wynne
    Margaret W. Colton
    Mariafausta Fischietti
    Elspeth M. Beauchamp
    Jason X. Cheng
    Olatoyosi Odenike
    Gail Roboz
    Houda Alachkar
    Wendy Stock
    Blood Cancer Journal, 11
  • [2] OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia
    Eisfelder, Bartholomew J.
    Saygin, Caner
    Wynne, Joseph
    Colton, Margaret W.
    Fischietti, Mariafausta
    Beauchamp, Elspeth M.
    Cheng, Jason X.
    Odenike, Olatoyosi
    Roboz, Gail
    Alachkar, Houda
    Stock, Wendy
    BLOOD CANCER JOURNAL, 2021, 11 (03)
  • [3] Inhibition of FLT3-ITD and Melk By Small Molecule Inhibitor OTS167 in FLT3 mutant Acute Myeloid Leukemia (AML)
    Eisfelder, Bartholomew
    Alachkar, Houda
    Colton, Margaret
    Fulton, Noreen
    Odenike, Olatoyosi
    Nakamura, Yusuke
    Stock, Wendy
    BLOOD, 2017, 130
  • [4] Incorporating FLT3 inhibitors in the frontline treatment of FLT3 mutant acute myeloid leukemia
    Wang, Eunice S.
    BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2019, 32 (02) : 154 - 162
  • [5] Targeting on glycosylation of mutant FLT3 in acute myeloid leukemia
    Hu, Xiaoli
    Chen, Fangyuan
    HEMATOLOGY, 2019, 24 (01) : 651 - 660
  • [6] Glucocorticoids act synergistically with FLT3 inhibitors to enhance cell death in FLT3 mutant acute myeloid leukemia
    Gebru, Melat Tsegaye
    Wang, Hong-Gang
    Xavier, Jennifer
    CANCER RESEARCH, 2020, 80 (16)
  • [7] FLT3 Inhibition in Acute Myeloid Leukemia
    Smith, Catherine C.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2020, 20 : S5 - S6
  • [8] FLT3 inhibitors in acute myeloid leukemia
    Wu, Mei
    Li, Chuntuan
    Zhu, Xiongpeng
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018, 11
  • [9] FLT3 Inhibitors in Acute Myeloid Leukemia
    Stone, Richard M.
    ONCOLOGIST, 2016, 21 : S2 - S2
  • [10] FLT3 inhibitors in acute myeloid leukemia
    Mei Wu
    Chuntuan Li
    Xiongpeng Zhu
    Journal of Hematology & Oncology, 11