Valproate-associated dysmyelopoiesis in elderly patients

被引：14
|
作者：
So, CC [1 ]
Wong, KF [1 ]
机构：
[1] Queen Elizabeth Hosp, Dept Pathol, Kowloon, Hong Kong, Peoples R China
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2002年 / 118卷 / 02期
关键词：
sodium valproate; hematologic toxicity; dysmyelopoiesis; myelodysplasia; elderly;
D O I：
10.1309/4TEF-LVGX-WEQ9-R8W8
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Sodium valproate is widely prescribed for patients with epilepsy and psychiatric disorders. Hematologic toxic effects have been largely described in pediatric patients, and dysmyelopoiesis is reported rarely. We describe 21 elderly patients with valproate-associated dysmyelopoiesis and postulate that this particular side effect may be much more common than currently recognized. A correct diagnosis is important for acute patient management and for prognostication.
引用
收藏
页码：225 / 228
页数：4
相关论文
共 50 条
  • [41] UNUSUAL ELECTRON-MICROSCOPIC CHANGES IN VALPROATE-ASSOCIATED LIVER-FAILURE
    CAPARROSLEFEBVRE, D
    LECOMTEHOUCKE, M
    PRUVOT, FR
    DECLERCK, N
    PARIS, JC
    PETIT, H
    LANCET, 1993, 341 (8860): : 1604 - 1604
  • [42] Neutropenia Associated With the Comedication of Quetiapine and Valproate in 2 Elderly Patients
    Hung, Wei-Chih
    Hsieh, Ming H.
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2012, 32 (03) : 416 - 417
  • [43] Valproate-Associated Hyperammonemic Encephalopathy Clinical Correlates and Management Strategies in a Tertiary Care Center
    Vaidyanathan, Sivapriya
    Chatorikar, Shalaka
    Praharaj, Samir Kumar
    Munoli, Ravindra Neelakanthappa
    Udupa, Suma T.
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2023, 43 (02) : 145 - 148
  • [44] Dopaminergic Drugs and Valproate-associated Refractory Hyponatremia Over Levosulpiride-induced Parkinsonism in an Elderly Female Patient When Deprescribing was the Only Therapy
    Dehade, Amol
    Chakrabarti, Sankha Shubhra
    Reddy, Noti Taruni Srija
    Kaur, Upinder
    CURRENT DRUG SAFETY, 2024,
  • [45] DETECTION BY HPLC-ICP OF METALLOTHIONEIN IN SERUM OF AN EPILEPTIC-CHILD WITH VALPROATE-ASSOCIATED HEPATOTOXICITY
    BRATTER, P
    BRUNETTO, R
    GRAMM, HJ
    RECKNAGEL, S
    SIEMES, H
    JOURNAL OF TRACE ELEMENTS AND ELECTROLYTES IN HEALTH AND DISEASE, 1992, 6 (04): : 251 - 255
  • [46] Valproate-associated reproductive and metabolic abnormalities:: are epileptic women at greater risk than bipolar women?
    Akdeniz, F
    Taneli, F
    Noyan, A
    Yüncü, Z
    Vahip, S
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2003, 27 (01): : 115 - 121
  • [47] Orthotopic liver transplantation with poor neurologic outcome in valproate-associated liver failure: A need for critical risk-benefit appraisal in the use of valproate
    Thomson, MA
    Lynch, S
    Strong, R
    Shepherd, RW
    Marsh, W
    TRANSPLANTATION PROCEEDINGS, 2000, 32 (01) : 200 - 203
  • [48] Valproate-Associated Reproductive Hormone Abnormalities: Do Bipolar Men have the Same Risk as Epileptic Men?
    Aldemir, Ebru
    Akdeniz, Fisun
    Altay, Ahmet Baris
    Arici, Sehnaz
    Umul, Mehmet
    Aydin, Hikmet Hakan
    Celebisoy, Mehmet
    Vahip, Simavi
    TURK PSIKIYATRI DERGISI, 2012, 23 (04) : 223 - 228
  • [49] Quetiapine- and Valproate-Associated Neutropenia and Thrombocytopenia After Lamotrigine-Induced Steven-Johnson Syndrome
    Chang, Li-Ren
    Chang, Hung-Chieh Wu
    Lin, Yu-Hsuan
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2012, 32 (01) : 133 - 134
  • [50] Topiramate enhances the risk of valproate-associated side effects in three children (vol 43, pg 451, 2002)
    Longin, E
    Teich, M
    König, S
    EPILEPSIA, 2002, 43 (09) : 1110 - 1110
12345