DETECTION BY HPLC-ICP OF METALLOTHIONEIN IN SERUM OF AN EPILEPTIC-CHILD WITH VALPROATE-ASSOCIATED HEPATOTOXICITY

被引：0

作者：

BRATTER, P

BRUNETTO, R

GRAMM, HJ

RECKNAGEL, S

SIEMES, H

机构：

[1] FREE UNIV BERLIN,KLIN STEGLITZ,ANAESTHESIOL & OPERAT INTENS MED KLIN,W-1000 BERLIN 33,GERMANY

[2] RITTBERG KRANKENHAUS BERLIN,KINDERKLIN,BERLIN,GERMANY

来源：

JOURNAL OF TRACE ELEMENTS AND ELECTROLYTES IN HEALTH AND DISEASE | 1992年 / 6卷 / 04期

关键词：

ELEMENT SPECIATION; METALLOTHIONEIN; VALPROATE THERAPY; HEPATOTOXICITY; SELENIUM; COPPER; ZINC; CADMIUM; SULFUR; HPLC-ICP;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A patient who developed valproate-associated hepatotoxicity had significantly lower serum levels of total protein, albumin and selenium than the controls. This study shows that with the beginning of the hepatic coma metallothionein (MT) appeared in the serum mainly in the form of Zn-thionein, which altered the Zn distribution pattern of the serum in a characteristic manner. HPLC-ICP3 was successfully applied to the simultaneous speciation of elements and characterization of MT by the use of one gel permeation column.

引用

页码：251 / 255

页数：5