共 50 条
- [1] Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (13) : 6407 - 6430Pettus, Liping H.Andrews, Kristin L.Booker, Shon K.Chen, JieCee, Victor J.Chavez, Frank, Jr.Chen, YupingEastwood, HeatherGuerrero, NadiaHerberich, BradleyHickman, DeanLanman, Brian A.Laszlo, Jimmy, IIILee, Matthew R.Lipford, J. RussellMattson, BethanyMohr, ChristopherYen NguyenNorman, Mark H.Powers, DavidReed, Anthony B.Rex, KarenSastri, ChristineTamayo, NuriaWang, PaulWinston, Jeffrey T.Wu, BinWu, TianWurz, Ryan P.Xu, YangZhou, YihongTasker, Andrew S.Wang, Hui-Ling
- [2] Discovery and optimization of potent, selective, and orally bioavailable Jak1 inhibitorsABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243Zak, MarkJohnson, AdamVan Abbema, AnneWaszkowycz, BohdanEigenbrot, CharlesChang, ChristineHurley, ChristopherHanan, EmilyKenny, JaneKulagowski, JanuszDeVoss, JasonMurray, JeremyBalazs, MercedeszSteffek, MicahKoehler, MichaelGhilardi, NicoChakravarty, ParomaLupardus, PatrickGibbons, PaulDragovich, PeterBergeron, PhilippePulk, RebeccaMendonca, RohanSavage, ScottLabadie, SharadaGradl, StefanWard, StuartBlair, WadeJia, Wei
- [3] Discovery and optimization of orally bioavailable, selective and potent ATP-independent Akt inhibitorsCANCER RESEARCH, 2012, 72Chan, Thomas C. K.Ashwell, Mark A.Lapierre, Jean-MarcBrassard, ChristopherBull, CathyCornell-Kennon, SusanEathiraj, SudharshanFrance, Dennis S.Hill, JasonKoerner, SteffiKelleher, EoinKizer, DarinLiu, YanbinLink, JeffMakhija, SapnaMoussa, MagdiNamdev, NiveditaNicewonger, RobertUppalapati, UmaPalma, RocioSzwaya, JeffTandon, ManishVensel, DavidVolak, LaurieVolckova, ErikaWestland, NeilWu, HuiYang, Rui-Yang
- [4] The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (04) : 847 - 855Wurz, Ryan P.Pettus, Liping H.Jackson, ClaireWu, BinWang, Hui-LingHerberich, BradCee, VictorLanman, Brian A.Reed, Anthony B.Chavez, Frank, Jr.Nixey, ThomasLaszlo, Jimmy, IIIWang, PaulNguyen, YenSastri, ChristineGuerrero, NadiaWinston, JeffLipford, J. RussellLee, Matthew R.Andrews, Kristin L.Mohr, ChristopherXu, YangZhou, YihongReid, Darren L.Tasker, Andrew S.
- [5] Optimization of a series of potent, selective and orally bioavailable SYK inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (19)Grimster, Neil P.Gingipalli, LakshmaiahBarlaam, BernardSu, QibinZheng, XiaoLanWatson, DavidWang, HaixiaSimpson, IainPike, AndyBalazs, AmberBoiko, ScottIkeda, Timothy P.Impastato, Anna C.Jones, Natalie H.Kawatkar, SameerKemmitt, PaulLamont, ScottPatel, JoeRead, JonSarkar, UjjalSha, LiTomlinson, Ronald C.Wang, HaiyunWilson, David M.Zehnder, Troy E.Wang, LiangheWang, PengGoldberg, Frederick W.Shao, WenlinFawell, StephenDry, HannahDowling, James E.Edmondson, Scott D.
- [6] Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (11) : 5467 - 5482Leahy, James W.Buhr, Chris A.Johnson, Henry W. B.Kim, Byung GyuBaik, TaeGonCannoy, JonahForsyth, Timothy P.Jeong, Joon WonLee, Matthew S.Ma, SunghoonNoson, KevinWang, LongchengWilliams, MatthewNuss, John M.Brooks, EricFoster, PaulGoon, LeanneHeald, NathanHolst, CharlesJaeger, ChristopherLam, ScottLougheed, JulieLam NguyenPlonowski, ArthurSong, JoanneStout, ThomasWu, XiangYakes, Michael F.Yu, PeiwenZhang, WentaoLamb, PeterRaeber, Olivia
- [7] Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKTBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (10) : 1887 - 1891Parthasarathy, SaravananHenry, KennethPei, HuaxingClayton, JoshRempala, MarkJohns, DeidreDe Frutos, OscarGarcia, PabloMateos, CarlosPleite, SehilaWang, YongStout, StephanieCondon, BradleyAshok, SheelaLu, ZhohaiEhlhardt, WilliamRaub, TomLai, MeiGeeganage, SandaruwanBurkholder, Timothy P.
- [8] Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2ACS MEDICINAL CHEMISTRY LETTERS, 2022, : 1159 - 1164Nguyen, Minh H.Atasoylu, OnurWu, LiangxingKapilashrami, KanishkPusey, MichelleGallagher, KarenLai, Cheng-TsungZhao, PengBarbosa, JosephLiu, KaiHe, ChunhongZhang, ColinStyduhar, Evan D.Witten, Michael R.Chen, YaoyuLin, LupingYang, Yan-ouCovington, MaryanneDiamond, SharonYeleswaram, SwamyYao, Wenqing
- [9] Structure guided optimization of novel, selective, and orally bioavailable inhibitors of Pim kinasesABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245Nishiguchi, Gisele A.Burger, MatthewHan, WooseokLan, JiongAtallah, GordanaDing, YuMathur, MichelleMuller, KristineTamez, VictorianoLindvall, MikaBellamacina, CorneliaGarcia, PabloZavorotinskaya, TatianaFeucht, PaulLangowski, JohnZang, RichardDai, YuminChan, JulieHolash, JocelynHuh, Kay
- [10] Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (16) : 4579 - 4583Cox, Jason M.Harper, BartMastracchio, AnthonyLeiting, BarbaraRoy, Ranabir SinhaPatel, Reshma A.Wu, Joseph K.Lyons, Kathryn A.He, HuaibingXu, ShiyaoZhu, BingThornberry, Nancy A.Weber, Ann E.Edmondson, Scott D.