共 50 条
- [41] Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological EvaluationJOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (10) : 5242 - 5256Liu, ZhiqingChen, HaiyingWang, PingyuanLi, YiWold, Eric A.Leonard, Paul G.Joseph, SarahBrasier, Allan R.Tian, BingZhou, Jia
- [42] Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (14) : 6575 - 6596Lin, JianLu, WeiCaravella, Justin A.Campbell, Ann MarieDiebold, R. BruceEricsson, AnnaFritzen, EdwardGustafson, Gary R.Lancia, David R., Jr.Shelekhin, TatianaWang, ZhongguoCastro, JenniferClarke, AndreaGotur, DeepaliJosephine, Helen R.Katz, MarieDiep, HienKershaw, MarkYao, LiliKauffman, GossHubbs, Stephen E.Luke, George P.Toms, Angela V.Wang, LiannBair, Kenneth W.Barr, Kenneth J.Dinsmore, ChristopherWalker, DuncanAshwell, Susan
- [43] Discovery of Selective and Orally Bioavailable Protein Kinase Cθ (PKCθ) Inhibitors from a Fragment HitJOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (01) : 222 - 236George, Dawn M.Breinlinger, Eric C.Friedman, MichaelZhang, YangWang, JianfeiArgiriadi, MariaBansal-Pakala, PratimaBarth, MartineDuignan, David B.Honore, PriscaLang, QiugYuMittelstadt, ScottPotin, DominiqueRundell, LianEdmunds, Jeremy J.
- [44] Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na+/H+ Exchanger Type 3 (NHE3)JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (19) : 8812 - 8829Rackelmann, NilsMatter, HansEnglert, HeinrichFollmann, MarkusMaier, ThomasWeston, JohnArndt, PetraHeyse, WinfriedMertsch, KatharinaWirth, KlausBialy, Laurent
- [45] Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (17) : 4034 - 4038Ding, XiaoDai, XuedongLong, KaiPeng, ChengAndreotti, DanieleBamborough, PaulEatherton, Andrew J.Edge, ColinJandu, Karamjit S.Nichols, Paula L.Philps, Oliver J.Stasi, Luigi PieroWan, ZehongXiang, Jia-NingDong, KellyDossang, PamelaHo, Ming-HsunLi, YiMensah, LucyGuan, XiaomingReith, Alastair D.Ren, Feng
- [46] Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U218 - U218Edmondson, SDMastracchio, ADuffy, JLEiermann, GJHe, HBLeiting, BLeone, JFLyons, KAMakarewicz, AMPatel, RAPetrov, AWu, JKThornberry, NAWeber, AE
- [47] Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (05) : 1346 - 1349Xu, JYWei, LMathvink, REdmondson, SDMastracchio, AEiermann, GJHe, HBLeone, JFLeiting, BLyons, KAMarsilio, FPatel, RAPetrov, AWu, JKThornberry, NAWeber, AE
- [48] Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (11) : 4320 - 4342Bregman, HowardChakka, NagasreeGuzman-Perez, AngelGunaydin, HakanGu, YanHuang, XinBerry, VirginiaLiu, JingzhouTeffera, YohannesHuang, LiyueEgge, BryanMullady, Erin L.Schneider, SteveAndrews, Paul S.Mishra, AnkitaNewcomb, JohnSerafino, RandyStrathdee, Craig A.Turci, Susan M.Wilson, CindyDiMauro, Erin F.
- [49] Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (09) : 1615 - 1620Ding, XiaoStasi, Luigi PieroHo, Ming-HsunZhao, BaoweiWang, HailongLong, KaiXu, QiongfengSang, YingxiaSun, ChanghuiHu, HuanYu, HaihuaWan, ZehongWang, LizhenEdge, ColinLiu, QianLi, YiDong, KellyGuan, XiaomingTattersall, F. DavidReith, Alastair D.Ren, Feng
- [50] MEDI 370-Evolution of selective, potent, and orally bioavailable small molecule Tie-2 kinase inhibitorsABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234Olivieri, Philip R., IIGeuns-Meyer, Stephanie D.Hughes, Paul E.Albrecht, Brian K.Bellon, SteveBready, JamesCaenepeel, SeanCee, Victor J.Chaffee, Stuart C.Coxon, AngelaEmery, MauriceFretland, JenneGallant, PaulGu, YanHodous, Brian L.Hoffman, DougJohnson, Rebecca E.Kendall, RichardKim, Joseph L.Long, Alexander M.Morrison, MichaelPatel, Vinod F.Polverino, AnthonyRose, PaulTempest, PaulWang, LingWhittington, Douglas A.Zhao, Huilin