Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives

被引：64
|
作者：
Periyasami, Govindasami [1 ]
Raghunathan, Raghavachary [1 ]
Surendiran, Gangadharan [2 ]
Mathivanan, Narayanasamy [2 ]
机构：
[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India
[2] Univ Madras, Ctr Adv Studies Bot, Madras 600025, Tamil Nadu, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 03期
关键词：
Keto-carbazole; Azomethine ylides; Cycloaddition; Dispiropyrrolidine; Bioactivity; HYACINTHOIDES-NON-SCRIPTA; PYRROLIZIDINE ALKALOIDS; PYRROLIDINE;
D O I：
10.1016/j.ejmech.2008.07.009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel dispiropyrrolidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from sarrosin and di/tri ketone with the dipolarophile (E)-2-arylidine-1-keto-carbazoles. The cycloadducts ketocarbazalo spiro N-methyl pyrrolidines showed the most interesting antimicrobial activity at lower concentration. (C) 2008 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：959 / 966
页数：8
相关论文
共 50 条
  • [1] Regioselective synthesis and antimicrobial activities of some novel aryloxyacetic acid derivatives
    Abdel-Wahab, Bakr F.
    Khidre, Rizk E.
    Awad, Ghada E. A.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 50 : 55 - 62
  • [2] SYNTHESIS AND SCREENING OF ANTIMICROBIAL ACTIVITY OF NOVEL PYRROLE DERIVATIVES
    Hallikeri, C. S.
    Joshi, S. D.
    More, Uttam A.
    Kulkarni, V. H.
    [J]. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 23 (03) : 249 - 252
  • [3] Synthesis and Antimicrobial Screening of Some Novel Pyrazoline Derivatives
    Kundariya, D. S.
    Rupala, R. G.
    Patel, P. K.
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2012, 24 (05) : 2045 - 2048
  • [4] Facile Regioselective Synthesis of Novel bis-Thiazole Derivatives and Their Antimicrobial Activity
    Mahmoodi, Nosrat O.
    Parvizi, Jafar
    Sharifzadeh, Bahman
    Rassa, Mehdi
    [J]. ARCHIV DER PHARMAZIE, 2013, 346 (12) : 860 - 864
  • [5] Synthesis, characterization and antimicrobial screening of some novel chalcones and their derivatives
    Chate, Asha V.
    Joshi, Ratnadeep S.
    Mandhane, Priyanka G.
    Gill, Charansingh H.
    [J]. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2012, 51 (11): : 1642 - 1648
  • [6] Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives
    Farag, Ahmad M.
    Mayhoub, Abdelrahman S.
    Barakat, Saber E.
    Bayomi, Ashraf H.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (02) : 881 - 889
  • [7] Regioselective and efficient enzymatic synthesis of antimicrobial andrographolide derivatives
    Patil, Harshal S.
    Jadhav, Dipesh D.
    Paul, Ajay
    Mulani, Fayaj A.
    Karegaonkar, Shrikant J.
    Thulasiram, Hirekodathakallu V.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (06) : 1132 - 1137
  • [8] SYNTHESIS AND SCREENING OF ANTIMICROBIAL ACTIVITY OF NOVEL PYRROLYL-PYRAZOLE DERIVATIVES
    Hallikeri, C. S.
    Joshi, Shrinivas D.
    Kumar, Devendra
    Kulkarni, V. H.
    Selvam, Theivendren Paneer
    [J]. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 24 (03) : 261 - 264
  • [9] Synthesis, characterization and antimicrobial screening of novel quinoline-thiazole derivatives
    Desai, N. C.
    Shihory, Niraj
    Rajpara, Kiran
    Dodiya, Amit
    [J]. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2012, 51 (03): : 508 - 513
  • [10] One Pot Regioselective Synthesis and Antimicrobial Studies of Some Novel Indazolyl-Thiazole Derivatives
    Gautam, Poonam
    Gautam, Deepika
    Chaudhary, R. P.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 53 (01) : 294 - 302
12345