Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives

被引：64
|
作者：
Periyasami, Govindasami [1 ]
Raghunathan, Raghavachary [1 ]
Surendiran, Gangadharan [2 ]
Mathivanan, Narayanasamy [2 ]
机构：
[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India
[2] Univ Madras, Ctr Adv Studies Bot, Madras 600025, Tamil Nadu, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 03期
关键词：
Keto-carbazole; Azomethine ylides; Cycloaddition; Dispiropyrrolidine; Bioactivity; HYACINTHOIDES-NON-SCRIPTA; PYRROLIZIDINE ALKALOIDS; PYRROLIDINE;
D O I：
10.1016/j.ejmech.2008.07.009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel dispiropyrrolidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from sarrosin and di/tri ketone with the dipolarophile (E)-2-arylidine-1-keto-carbazoles. The cycloadducts ketocarbazalo spiro N-methyl pyrrolidines showed the most interesting antimicrobial activity at lower concentration. (C) 2008 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：959 / 966
页数：8
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