Synthesis, characterization and antimicrobial screening of novel quinoline-thiazole derivatives

2-Chloroquinoline-3-earbaldehyde 1 reacts with 2-cyanoacetohydrazide in ethanol to result in 1-[1-aza-2-(2-chloro(3-quinolyl))vinyl]-2-cyanoacetamide 2. Phenyl isothiocyanate added to a stirred solution of compound 2, sulphur and triethylamine in a mixed solvent of dimethylformamide : ethanol to result in N-[1-aza-2-(2-chloro(3-quinolyl))vinyl](4-amino-3-phenyl-2-thioxo(1,3-thiazoline-5-yl)) carboxamide 3. Compound 3 reacts with different aldehydes in ethanol to yield (4-[1-aza-2-(aryl)vinyl]-3-pheny1-2-thioxo(1,3-thiazolin-5-yl))-N-[1-aza-2-(2-chloro(3-quinolyl))vinyl]carboxamides 4a-I. These newly synthesized compounds 4a-I have been screened for their antibacterial activity on Escherichia coli, Pseudomonas aeruginosa, Staphylococcus czureus and Streptococcus pyogenes, and antifungal activity on Candida albicans, Aspergillus niger and Aspergillus clavatus.