Synthesis of lithium, sodium, cesium, and calcium salts of (E)-4-or (E,S)-3-methyl-2-(5-arylisoxazol-3-yl)-methyleneaminobutanoic, (E,S)-4-methyl-2-or (E,2S,3S)-3-methyl-2-(5-arylisoxazol-3-yl)methyleneaminopentanoic, and (E)-6-(5-arylisoxazol-3-yl)methyleneaminohexanoic acids

被引：1
|
作者：
Dikusar, E. A. [1 ]
Potkin, V. I. [1 ]
Pyatkevich, S. K. [1 ]
机构：
[1] Natl Acad Sci Belarus, Inst Phys Organ Chem, Minsk 220072, BELARUS
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2014年 / 84卷 / 09期
关键词：
salts of 5-arylisoxazol-3-ylmethyleneaminocarboxylic acids; azomethines; synthesis; heterocyclic compounds; amino acids; BIOLOGICAL-ACTIVITY; AMINO-ACIDS;
D O I：
10.1134/S1070363214090102
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Preparative method for the synthesis of lithium, sodium, cesium, and calcium salts of (E)-4-(5-arylisoxazol-3-yl)methyleneaminobutanoic, (E)-6-(5-arylisoxazol-3-yl)methyleneaminohexanoic, (E,S)-3-methyl-2-(5-arylisoxazol-3-yl)methyleneaminobutanoic, (E,S)-4-methyl-2-(5-arylisoxazol-3-yl)methyleneaminopentanoic and (E,2S,3S)-3-methyl-2-(5-arylisoxazol-3-yl)methyleneaminopentanoic acids was developed by reacting 5-phenyl(4-tolyl)isoxazole-3-carbaldehydes with amino acids like 4-aminobutyric and 6-aminocaproic acids, L-valine, L-leucine or L-isoleucine in the presence of lithium hydride, sodium methoxide, cesium carbonate or calcium hydride in boiling methanol.
引用
收藏
页码：1701 / 1705
页数：5
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