2-Amino-3-cyano-4-(5-arylisoxazol-3-yl)-4H-chromenes: Synthesis and In Vitro Cytotoxic Activity

被引：51
|
作者：
Akbarzadeh, Tahmineh [1 ,2 ]
Rafinejad, Ali [1 ,2 ]
Mollaghasem, Javad Malekian [1 ,2 ]
Safavi, Maliheh [1 ,2 ,3 ]
Fallah-Tafti, Asal [1 ,2 ]
Pordeli, Mahboobeh [3 ]
Ardestani, Sussan Kabudanian [3 ]
Shafiee, Abbas [1 ,2 ]
Foroumadi, Alireza [1 ,2 ]
机构：
[1] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran, Iran
[2] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran
[3] Univ Tehran, Inst Biochem & Biophys, Dept Biochem, Tehran, Iran
来源：
ARCHIV DER PHARMAZIE | 2012年 / 345卷 / 05期
关键词：
4-(5-Arylisoxazol-3-yl)-4H-chromenes; Cancer; Cytotoxic activity; Synthesis; THROUGHPUT SCREENING ASSAY; APOPTOSIS INDUCERS; SERIES; DISCOVERY; 4-ARYL-4H-CHROMENES; PROLIFERATION;
D O I：
10.1002/ardp.201100345
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new series of 4-aryl-4H-chromenes bearing a 5-arylisoxazol-3-yl moiety at the C-4 position were prepared as potential anticancer agents. The in vitro cytotoxic activity of the synthesized compounds was investigated against a panel of tumor cell lines including MCF-7 (breast cancer), KB (nasopharyngeal epidermoid carcinoma), Hep-G2 (liver carcinoma), MDA-MB-231 (breast cancer), and SKNMC (human neuroblastoma) using the MTT colorimetric assay. Doxorubicin, a well-known anticancer drug, was used as positive standard drug. Among the synthesized compounds, the 5-(3-methylphenyl)isoxazol-3-yl analog (7j) showed the most potent cytotoxic activity against all five human tumor cell lines.
引用
收藏
页码：386 / 392
页数：7
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