Synthesis of lithium, sodium, cesium, and calcium salts of (E)-4-or (E,S)-3-methyl-2-(5-arylisoxazol-3-yl)-methyleneaminobutanoic, (E,S)-4-methyl-2-or (E,2S,3S)-3-methyl-2-(5-arylisoxazol-3-yl)methyleneaminopentanoic, and (E)-6-(5-arylisoxazol-3-yl)methyleneaminohexanoic acids

被引：1

作者：

Dikusar, E. A. ^{[1
]}

Potkin, V. I. ^{[1
]}

Pyatkevich, S. K. ^{[1
]}

机构：

[1] Natl Acad Sci Belarus, Inst Phys Organ Chem, Minsk 220072, BELARUS

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2014年 / 84卷 / 09期

关键词：

salts of 5-arylisoxazol-3-ylmethyleneaminocarboxylic acids; azomethines; synthesis; heterocyclic compounds; amino acids; BIOLOGICAL-ACTIVITY; AMINO-ACIDS;

D O I：

10.1134/S1070363214090102

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Preparative method for the synthesis of lithium, sodium, cesium, and calcium salts of (E)-4-(5-arylisoxazol-3-yl)methyleneaminobutanoic, (E)-6-(5-arylisoxazol-3-yl)methyleneaminohexanoic, (E,S)-3-methyl-2-(5-arylisoxazol-3-yl)methyleneaminobutanoic, (E,S)-4-methyl-2-(5-arylisoxazol-3-yl)methyleneaminopentanoic and (E,2S,3S)-3-methyl-2-(5-arylisoxazol-3-yl)methyleneaminopentanoic acids was developed by reacting 5-phenyl(4-tolyl)isoxazole-3-carbaldehydes with amino acids like 4-aminobutyric and 6-aminocaproic acids, L-valine, L-leucine or L-isoleucine in the presence of lithium hydride, sodium methoxide, cesium carbonate or calcium hydride in boiling methanol.

引用

页码：1701 / 1705

页数：5

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