Preparative synthesis of polysubstituted 4-(5-arylisoxazol-3-yl)-1,4-dihydropyridines and -pyridines

被引：0

作者：

Sergey K. Petkevich

Tatsiana D. Zvereva

Polina S. Shabunya

Hongwei Zhou

Eugeniya V. Nikitina

Anastasiya А. Ershova

Vladimir P. Zaytsev

Victor N. Khrustalev

Anna А. Romanycheva

Anton А. Shetnev

Vladimir I. Potkin

机构：

[1] National Academy of Sciences of Belarus,Institute of Physical Organic Chemistry

[2] National Academy of Sciences of Belarus,Institute of Bioorganic Chemistry

[3] Jiaxing University,College of Biological, Chemical Sciences and Engineering

[4] RUDN University,N. D. Zelinsky Institute of Organic Chemistry

[5] Russian Academy of Sciences,undefined

[6] Yaroslavl State Pedagogical University named after K. D. Ushinsky,undefined

来源：

Chemistry of Heterocyclic Compounds | 2022年 / 58卷

关键词：

aldehydes; 1,4-dihydropyridines; isoxazoles; pyridines; Hantzsch reaction;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Multicomponent condensation of 5-phenyl(p-tolyl)isoxazole-3-carbaldehydes, cyclohexane-1,3-dione (or dimedone), ethyl acetoacetate (or acetylacetone), and ammonium acetate was used to synthesize polysubstituted derivatives of 1,4-dihydropyridines with an isoxazole fragment. As a result of oxidation of the obtained compounds with sodium nitrite, the corresponding substituted pyridine derivatives were formed. Biological testing revealed that some of the obtained compounds exhibited cytotoxic activity against LS174T colorectal cancer cells, as well as antibacterial activity against susceptible strains of Escherichia coli (C600) and Staphylococcus aureus (ATCC-25923).

引用

页码：333 / 341

页数：8

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