Synthesis of novel 4-(5′-pyrrolidinyl)-β-lactams

被引：45

作者：

Grigg, R ^{[1
]}

Thornton-Pett, M ^{[1
]}

Xu, J ^{[1
]}

Xu, LH ^{[1
]}

机构：

[1] Univ Leeds, Sch Chem, Mol Innovat Divers & Automated Synth Ctr, Leeds LS2 9JT, W Yorkshire, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 48期

关键词：

beta-lactams; azomethine ylide; cycloaddition; cascade reaction;

D O I：

10.1016/S0040-4020(99)00867-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of novel 4-(5'-pynolidinyl)-beta-lactams from imines derived from 4-formyl-beta-lactams and alpha-amino esters via cascade imine-->azomethine ylide-->1,3-dipolar cycloaddition reactions is described. These cascades are endo-specific, exhibit facial stereoselectivity and occur in good to excellent yields. (C) 1999 Elsevier Science Ltd. Ail rights reserved.

引用

页码：13841 / 13866

页数：26

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