Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents

被引：9
|
作者：
Arai, M
Harasaki, T
Fukuoka, T
Kaneko, S
Konosu, T
机构：
[1] Sankyo Co Ltd, Med Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan
[2] Sankyo Co Ltd, Biol Res Labs, Shinagawa Ku, Tokyo 1408710, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 19期
关键词：
D O I：
10.1016/S0960-894X(02)00534-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
N-Benzyl pyrrolidinyl sordaricin derivatives have been synthesized from cis-4-hydroxy-D-proline in a stereocontrolled manner. These compounds maintained moderate antifungal activity against several pathogenic fungal strains. Their MIC values against Candida albicans were in the range of 0.25-2 mug/mL. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2733 / 2736
页数：4
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