A clinical isolate of Escherichia coli co-harbouring mcr-1 and blaNDM-5 in Japan

被引：15
|
作者：
Uchida, Hiroki [1 ]
Tada, Tatsuya [1 ]
Sugahara, Yoshie [2 ]
Kato, Akira [3 ]
Miyairi, Isao [4 ,5 ]
Kirikae, Teruo [1 ]
机构：
[1] Juntendo Univ, Dept Microbiol, Sch Med, Bunkyo Ku, Tokyo 1138421, Japan
[2] Natl Ctr Child Hlth & Dev, Dept Nursing, Setagaya Ku, Tokyo 1578535, Japan
[3] Natl Ctr Child Hlth & Dev, Dept Clin Lab Med, Clin Microbiol Lab, Setagaya Ku, Tokyo 1578535, Japan
[4] Natl Child Hlth & Dev, Div Infect Dis, Dept Med Subspecialties, Setagaya Ku, Tokyo 1578535, Japan
[5] Univ Tennessee, Hlth Sci Ctr, Dept Microbiol Immunol & Biochem, Memphis, TN 38138 USA
来源：
JOURNAL OF MEDICAL MICROBIOLOGY | 2018年 / 67卷 / 08期
基金：
日本学术振兴会;
关键词：
CRE; colistin resistance; Mcr-1; NDM-5; BETA-LACTAMASE; PLASMIDS;
D O I：
10.1099/jmm.0.000793
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mcr-1 gene encodes a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. This study describes the emergence of a colistin- and carbapenem-resistant clinical isolate of Escherichia coli harbouring mcr-1 and bla(NDM-5) genes, located on 90 and 150 Kb plasmids, respectively. The isolate belonged to ST132. This is the first report of a clinical isolate in Japan co-harbouring mcr-1 and bla(NDM-5).
引用
收藏
页码：1047 / 1049
页数：3
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