Co-transfer of blaNDM-5 and mcr-1 by an IncX3-X4 hybrid plasmid in Escherichia coli

被引：0
|
作者：
Sun J. [1 ,2 ]
Yang R.-S. [1 ,2 ]
Zhang Q. [3 ]
Feng Y. [4 ]
Fang L.-X. [1 ,2 ]
Xia J. [1 ,2 ]
Li L. [1 ,2 ]
Lv X.-Y. [1 ,2 ]
Duan J.-H. [1 ,2 ]
Liao X.-P. [1 ,2 ]
Liu Y.-H. [1 ,2 ,5 ]
机构：
[1] National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou
[2] College of Veterinary Medicine, South China Agricultural University, Guangzhou
[3] Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, 50011, IA
[4] Department of Medical Microbiology and Parasitology, Zhejiang University, School of Medicine, Zhejiang
[5] Jiangsu Co-Innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu
来源：
Nature Microbiology | / 1卷 / 12期
关键词：
D O I：
10.1038/nmicrobiol.2016.176
中图分类号：
学科分类号：
摘要：
Carbapenem and colistin are the last-resort antibiotics used for treating multidrug-resistant Gram-negative pathogens. Here, we report, for the first time, co-transfer of resistance to both classes of antibiotics by a mobile IncX3-X4 hybrid plasmid in an Escherichia coli isolate. Spread of such a plasmid is of great concern for clinical therapy, and heightened efforts are needed to control its dissemination. © 2016 Macmillan Publishers Limited, part of Springer Nature.
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