Co-transfer of blaNDM-5 and mcr-1 by an IncX3-X4 hybrid plasmid in Escherichia coli

被引：2
|
作者：
Sun, Jian [1 ,2 ]
Yang, Run-Shi [1 ,2 ]
Zhang, Qijing [3 ]
Feng, Youjun [4 ]
Fang, Liang-Xing [1 ,2 ]
Xia, Jing [1 ,2 ]
Li, Liang [1 ,2 ]
Lv, Xiao-Yue [1 ,2 ]
Duan, Jia-Hong [1 ,2 ]
Liao, Xiao-Ping [1 ,2 ]
Liu, Ya-Hong [1 ,2 ,5 ]
机构：
[1] South China Agr Univ, Natl Risk Assessment Lab Antimicrobial Resistance, Guangzhou 510642, Guangdong, Peoples R China
[2] South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China
[3] Iowa State Univ, Coll Vet Med, Dept Vet Microbiol & Prevent Med, Ames, IA 50011 USA
[4] Zhejiang Univ, Sch Med, Dept Med Microbiol & Parasitol, Hangzhou 310027, Peoples R China
[5] Jiangsu Coinnovat Ctr Prevent Control Important A, Yangzhou 225009, Jiangsu, Peoples R China
来源：
NATURE MICROBIOLOGY | 2016年 / 1卷 / 12期
关键词：
CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE; RESISTANCE GENE; IDENTIFICATION;
D O I：
10.1038/NMICROBIOL.2016.176
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Carbapenem and colistin are the last-resort antibiotics used for treating multidrug-resistant Gram-negative pathogens. Here, we report, for the first time, co-transfer of resistance to both classes of antibiotics by a mobile IncX3-X4 hybrid plasmid in an Escherichia coli isolate. Spread of such a plasmid is of great concern for clinical therapy, and heightened efforts are needed to control its dissemination.
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页数：4
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