CD74 Is Expressed in Relapsed and Refractory Multiple Myeloma and Can be Targeted with a Novel Anti-CD74 Antibody Drug Conjugate, STRO-001

被引：0
|
作者：
Embry, Millicent
Li, Xiaofan
Yu, Abigail
Abrahams, Cristina
Greenland, Nancy Y.
Wen, Kwun Wah
Jones, Chris
DeAlmeida, Venita
Krimm, Stellanie
Krueger, Sarah
Matheny, Shannon
Kline, Toni
Yam, Alice
Stafford, Ryan
Wiita, Arun P.
Hallam, Trevor
Lupher, Mark
Molina, Arturo
机构：
来源：
BLOOD | 2017年 / 130卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
4420
引用
收藏
页数：3
相关论文
共 50 条
  • [1] TARGETING CD74 IN MULTIPLE MYELOMA WITH A NOVEL ANTIBODY DRUG CONJUGATE, STRO-001
    Embry, M.
    Li, X.
    DeAlmeida, V.
    Abrahams, C.
    Yu, A.
    Krimm, S.
    Krueger, S.
    Matheny, S.
    Kline, T.
    Yam, A.
    Stafford, R.
    Hallam, T.
    Lupher, M.
    Molina, A.
    HAEMATOLOGICA, 2017, 102 : 106 - 106
  • [2] Therapeutic Targeting of CD74 with STRO-001 Antibody-Drug Conjugate in AML and ALL
    Le, Quy
    Leonti, Amanda R.
    Tang, Thao T.
    Castro, Sommer
    Nourigat-Mckay, Cynthia
    Perkins, LaKeisha
    Ries, Rhonda E.
    Smith, Jenny L.
    Hylkema, Tiffany A.
    Pardo, Laura
    Abrahams, Cristina
    Bedard, Kristin
    Molina, Arturo
    Brodersen, Lisa Eidenschink
    Loken, Michael R.
    Meshinchi, Soheil
    BLOOD, 2021, 138
  • [3] Preclinical studies targeting CD74 with STRO-001 antibody-drug conjugate in acute leukemia
    Le, Quy
    Tang, Thao
    Leonti, Amanda
    Castro, Sommer
    McKay, Cyd Nourigat
    Perkins, LaKeisha
    Pardo, Laura
    Kirkey, Danielle
    Hylkema, Tiffany
    Call, Lindsey
    Manselle, Makia
    Abrahams, Cristina
    Bedard, Kristin
    Molina, Arturo
    Brodersen, Lisa Eidenshinck
    Loken, Michael R.
    Tarlock, Katherine
    Meshinchi, Soheil
    Loeb, Keith R.
    BLOOD ADVANCES, 2023, 7 (09) : 1666 - 1670
  • [4] STRO-001, A NOVEL ANTI-CD74 ANTIBODY DRUG CONJUGATE (ADC) FOR TREATMENT OF B-CELL NON-HODGKIN'S LYMPHOMA (NHL)
    Yu, A.
    Abrahams, C.
    Embry, M.
    Li, X.
    DeAlmeida, V.
    Lee, J.
    Matheny, S.
    Kline, T.
    Yam, A.
    Stafford, R.
    Hallam, T.
    Lupher, M.
    Molina, A.
    HAEMATOLOGICA, 2017, 102 : 564 - 564
  • [5] Nonclinical safety evaluation of STRO-001, a site-specific anti-CD74 antibody-drug conjugate for the potential treatment of B-cell malignancies
    Solis, Willy
    De Almeida, Venita
    Yu, Abigail
    Bruhns, Maureen
    Zawada, James
    Galan, Adam
    Matheny, Shannon
    Molina, Arturo
    Hallam, Trevor
    Lupher, Mark
    CANCER RESEARCH, 2018, 78 (13)
  • [6] High Frequency of CD74 Expression in B-Cell Non-Hodgkin's Lymphoma (NHL) and Targeting with STRO-001, a Novel Anti-CD74 Antibody Drug Conjugate (ADC) with Potent I n Vitro Cytotoxicty and In Vivo Anti-Tumor Activity
    Yu, Abigail
    Abrahams, Cristina
    Embry, Millicent
    Li, Xiaofan
    Zhao, Shuchun
    Henningsen, Robert
    DeAlmeida, Venita
    Matheny, Shannon
    Kline, Toni
    Yam, Alice
    Stafford, Ryan
    Natkunam, Yasodha
    Hallam, Trevor
    Lupher, Mark
    Molina, Arturo
    BLOOD, 2017, 130
  • [7] High frequency of CD74 expression in lymphomas: implications for targeted therapy using a novel anti-CD74-drug conjugate
    Zhao, Shuchun
    Molina, Arturo
    Yu, Abigail
    Hanson, Jeff
    Cheung, Harry
    Li, Xiaofan
    Natkunam, Yasodha
    JOURNAL OF PATHOLOGY CLINICAL RESEARCH, 2019, 5 (01): : 12 - 24
  • [8] A Phase I open-label, safety, pharmacokinetic, and preliminary efficacy study of STRO-001, an anti-CD74 antibody drug conjugate, in patients with advanced B-cell malignancies
    Shah, Nirav N.
    Krishnan, Amrita Y.
    Shah, Nina D.
    Burke, John M.
    Melear, Jason M.
    Spira, Alexander I.
    Kaufman, Jonathan L.
    Cohen, Jonathon B.
    Niesvizky, Ruben
    Popplewell, Leslie L.
    Chhabra, Saurabh
    Sharman, Jeff P.
    Martin, Thomas G.
    Matheny, Shannon L.
    Leonard, John P.
    Molina, Arturo
    CANCER RESEARCH, 2019, 79 (13)
  • [9] Preliminary Results of an Ongoing Phase 1 Dose Escalation Study of the Novel Anti-CD74 Antibody Drug Conjugate (ADC), STRO-001, in Patients with B-Cell Non-Hodgkin Lymphoma
    Shah, Nirav N.
    Mattour, Ahmad H.
    Popplewell, Leslie L.
    Andreadis, Charalambos
    Melear, Jason M.
    Spira, Alexander I.
    Shulman, Jonah
    Manda, Sudhir
    Burke, John M.
    Chhabra, Saurabh
    Sharman, Jeff P.
    Krishnan, Amrita
    Shah, Nina
    Dilea, Clifford
    Kuriakose, Jason
    Berman, Craig Jerome
    Matheny, Shannon L.
    Leonard, John P.
    Molina, Arturo
    BLOOD, 2020, 136
  • [10] CD74 is expressed by multiple myeloma and is a promising target for therapy
    Burton, JD
    Ely, S
    Reddy, PK
    Stein, R
    Gold, DV
    Cardillo, TM
    Goldenberg, DM
    CLINICAL CANCER RESEARCH, 2004, 10 (19) : 6606 - 6611
12345