A Phase I open-label, safety, pharmacokinetic, and preliminary efficacy study of STRO-001, an anti-CD74 antibody drug conjugate, in patients with advanced B-cell malignancies

被引：1

作者：

Shah, Nirav N. ^{[1
]}

Krishnan, Amrita Y. ^{[2
]}

Shah, Nina D. ^{[3
]}

Burke, John M. ^{[4
]}

Melear, Jason M. ^{[5
]}

Spira, Alexander I. ^{[6
]}

Kaufman, Jonathan L. ^{[7
]}

Cohen, Jonathon B. ^{[7
]}

Niesvizky, Ruben ^{[8
]}

Popplewell, Leslie L. ^{[2
]}

Chhabra, Saurabh ^{[1
]}

Sharman, Jeff P. ^{[9
]}

Martin, Thomas G. ^{[3
]}

Matheny, Shannon L. ^{[10
]}

Leonard, John P. ^{[8
]}

Molina, Arturo ^{[10
]}

机构：

[1] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[2] City Hope Natl Med Ctr, Duarte, CA USA

[3] Univ Calif San Francisco, San Francisco, CA 94143 USA

[4] Rocky Mt Canc Centers, Aurora, CO USA

[5] Texas Oncol, Austin, TX USA

[6] Virginia Canc Specialists, Fairfax, VA USA

[7] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[8] New York Presbyterian Hosp, Cornell Campus, New York, NY USA

[9] Willamette Valley Canc Inst & Res Ctr, Eugene, OR USA

[10] Sutro Biopharma, San Francisco, CA USA

来源：

CANCER RESEARCH | 2019年 / 79卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2019-CT104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CT104

引用

页数：2

共 50 条

[1] A phase 1 open-label, safety, pharmacokinetic, and preliminary efficacy study of STRO-001, an anti-CD74 antibody drug conjugate, in patients with advanced B-cell malignancies.
Krishnan, Amrita Y.
Shah, Nina
Spira, Alexander I.
Kaufman, Jonathan L.
Niesvizky, Ruben
Shah, Nirav Niranjan
Burke, John M.
Popplewell, Leslie
Martin, Thomas G.
Cheung, Julee
Matheny, Shannon L.
Leonard, John Paul
Molina, Arturo
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
[2] Preliminary Results of a Phase 1 Dose Escalation Study of the First-in-Class Anti-CD74 Antibody Drug Conjugate (ADC), STRO-001, in Patients with Advanced B-Cell Malignancies
Shah, Nirav N.
Krishnan, Amrita Y.
Shah, Nina D.
Burke, John M.
Melear, Jason M.
Spira, Alexander I.
Popplewell, Leslie L.
Andreadis, Charalambos B.
Chhabra, Saurabh
Sharman, Jeff P.
Kaufman, Jonathan L.
Cohen, Jonathon B.
Niesvizky, Ruben
Martin, Thomas G., III
Dilea, Clifford
Kuriakose, Jason
Matheny, Shannon L.
Leonard, John P.
Molina, Arturo
BLOOD, 2019, 134
[3] Nonclinical safety evaluation of STRO-001, a site-specific anti-CD74 antibody-drug conjugate for the potential treatment of B-cell malignancies
Solis, Willy
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Yu, Abigail
Bruhns, Maureen
Zawada, James
Galan, Adam
Matheny, Shannon
Molina, Arturo
Hallam, Trevor
Lupher, Mark
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[4] Preliminary Results of an Ongoing Phase 1 Dose Escalation Study of the Novel Anti-CD74 Antibody Drug Conjugate (ADC), STRO-001, in Patients with B-Cell Non-Hodgkin Lymphoma
Shah, Nirav N.
Mattour, Ahmad H.
Popplewell, Leslie L.
Andreadis, Charalambos
Melear, Jason M.
Spira, Alexander I.
Shulman, Jonah
Manda, Sudhir
Burke, John M.
Chhabra, Saurabh
Sharman, Jeff P.
Krishnan, Amrita
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Matheny, Shannon L.
Leonard, John P.
Molina, Arturo
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[5] STRO-001, A NOVEL ANTI-CD74 ANTIBODY DRUG CONJUGATE (ADC) FOR TREATMENT OF B-CELL NON-HODGKIN'S LYMPHOMA (NHL)
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Embry, M.
Li, X.
DeAlmeida, V.
Lee, J.
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HAEMATOLOGICA, 2017, 102 : 564 - 564
[6] CD74 Is Expressed in Relapsed and Refractory Multiple Myeloma and Can be Targeted with a Novel Anti-CD74 Antibody Drug Conjugate, STRO-001
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[7] Characterization and preclinical development of STRO-001, a novel CD74-targeting antibody-drug conjugate (ADC) for the treatment of B-cell malignancies
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[8] High Frequency of CD74 Expression in B-Cell Non-Hodgkin's Lymphoma (NHL) and Targeting with STRO-001, a Novel Anti-CD74 Antibody Drug Conjugate (ADC) with Potent I n Vitro Cytotoxicty and In Vivo Anti-Tumor Activity
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[9] A Phase I, open-label, safety, pharmacokinetic, and preliminary efficacy study of STRO-002, an anti-folate receptor alpha (FolRα) antibody drug conjugate (ADC), in patients with advanced epithelial ovarian cancer (including fallopian tube or primary peritoneal cancers) and endometrial cancers
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