Lycopodium Alkaloids from Huperzia serrata

被引：13
|
作者：
Ying, You-Min [1 ]
Liu, Xiao-Sa [1 ]
Tong, Cui-Ping [1 ]
Wang, Jian-Wei [1 ]
Zhan, Zha-Jun [1 ]
Shan, Wei-Guang [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China
来源：
HELVETICA CHIMICA ACTA | 2014年 / 97卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Lycopodium alkaloids; Alkaloids; Huperzia serrata; -Glucosidase; Acetylcholinesterase; GLUCOSIDASE; SKELETON; AGENT;
D O I：
10.1002/hlca.201400015
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three new lycopodium alkaloids, huperserramines A-C (1-3, resp.), along with 15 known ones, lycopodine-6,11-diol (4), lycoposerramine H (5), lycoposerramine I (6), lycopodine-6-ol (7), lycoposerramine M (8), diphaladine A (9), lycoposerramine K (10), lycoposerramine W (11), huperzine M (12), luciduline (13), phlegmariuine N (14), huperzine A (15), huperzine B (16), lycodine (17), and lycoposerramine R (18), were isolated from the whole plant of Huperzia serrata. Their structures were established by spectroscopic methods, including 2D-NMR and MS analyses. All the isolates were evaluated for their inhibitory effects on acetylcholinesterase (AChE) and -glucosidase. As a result, lycopodine-6,11-diol (4) exhibited more potent -glucosidase inhibitory activity (IC50 148 +/- 5.5M) than the positive control acarbose (IC50 376.3 +/- 2.7M).
引用
收藏
页码：1433 / 1439
页数：7
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