Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

被引：13
|
作者：
Nguyen Ngoc Chuong [1 ]
Nguyen Thi Thu Huong [1 ]
Tran Manh Hung [2 ]
Tran Cong Luan [1 ]
机构：
[1] Res Ctr Ginseng & Med Mat, Ho Chi Minh City 70000, Vietnam
[2] Vietnam Natl Univ HoChiMinh City, Fac Chem, Univ Sci, Ho Chi Minh City 22701, Vietnam
来源：
MOLECULES | 2014年 / 19卷 / 11期
关键词：
Huperzia squarrosa; Lycopodiaceae; lycosquarosine A; acetylcholinesterase; Lycopodium alkaloids; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE INHIBITORS; DEMENTIA; TACRINE;
D O I：
10.3390/molecules191119172
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8 alpha-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 mu g/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 mu g/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors.
引用
收藏
页码：19172 / 19179
页数：8
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