Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

被引：13

作者：

Nguyen Ngoc Chuong ^{[1
]}

Nguyen Thi Thu Huong ^{[1
]}

Tran Manh Hung ^{[2
]}

Tran Cong Luan ^{[1
]}

机构：

[1] Res Ctr Ginseng & Med Mat, Ho Chi Minh City 70000, Vietnam

[2] Vietnam Natl Univ HoChiMinh City, Fac Chem, Univ Sci, Ho Chi Minh City 22701, Vietnam

来源：

MOLECULES | 2014年 / 19卷 / 11期

关键词：

Huperzia squarrosa; Lycopodiaceae; lycosquarosine A; acetylcholinesterase; Lycopodium alkaloids; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE INHIBITORS; DEMENTIA; TACRINE;

D O I：

10.3390/molecules191119172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8 alpha-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 mu g/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 mu g/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors.

引用

页码：19172 / 19179

页数：8