Lycopodium Alkaloids from Huperzia serrata

被引：13
|
作者：
Ying, You-Min [1 ]
Liu, Xiao-Sa [1 ]
Tong, Cui-Ping [1 ]
Wang, Jian-Wei [1 ]
Zhan, Zha-Jun [1 ]
Shan, Wei-Guang [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China
来源：
HELVETICA CHIMICA ACTA | 2014年 / 97卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Lycopodium alkaloids; Alkaloids; Huperzia serrata; -Glucosidase; Acetylcholinesterase; GLUCOSIDASE; SKELETON; AGENT;
D O I：
10.1002/hlca.201400015
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three new lycopodium alkaloids, huperserramines A-C (1-3, resp.), along with 15 known ones, lycopodine-6,11-diol (4), lycoposerramine H (5), lycoposerramine I (6), lycopodine-6-ol (7), lycoposerramine M (8), diphaladine A (9), lycoposerramine K (10), lycoposerramine W (11), huperzine M (12), luciduline (13), phlegmariuine N (14), huperzine A (15), huperzine B (16), lycodine (17), and lycoposerramine R (18), were isolated from the whole plant of Huperzia serrata. Their structures were established by spectroscopic methods, including 2D-NMR and MS analyses. All the isolates were evaluated for their inhibitory effects on acetylcholinesterase (AChE) and -glucosidase. As a result, lycopodine-6,11-diol (4) exhibited more potent -glucosidase inhibitory activity (IC50 148 +/- 5.5M) than the positive control acarbose (IC50 376.3 +/- 2.7M).
引用
收藏
页码：1433 / 1439
页数：7
相关论文
共 50 条
  • [21] Huperzine H, a New Lycopodium Alkaloid from Huperzia serrata
    Wen Yun GAO
    Yi M lug LI
    Bac De WANG
    Da Yuan ZHU(State Key Laboratory of New Drug Research. Shanghai Institute of Materia Medica. ChineseAcademy of Sciences
    ChineseChemicalLetters, 1999, (06) : 463 - 466
  • [22] Huperzine P, a novel Lycopodium alkaloid from Huperzia serrata
    Tan, CH
    Jiang, SH
    Zhu, DY
    TETRAHEDRON LETTERS, 2000, 41 (30) : 5733 - 5736
  • [23] Huperzine H, a new lycopodium alkaloid from Huperzia serrata
    Gao, WY
    Li, YM
    Wang, BD
    Zhu, DY
    CHINESE CHEMICAL LETTERS, 1999, 10 (06) : 463 - 466
  • [24] Huperzine V,: A new Lycopodium alkaloid from Huperzia serrata
    Liu, HQ
    Tan, CH
    Jiang, SH
    Zhu, DY
    CHINESE CHEMICAL LETTERS, 2004, 15 (03) : 303 - 304
  • [25] Three new Lycopodium alkaloids from Huperzia carinata and Huperzia squarrosa
    Thorroad, Sakornrat
    Worawittayanont, Prateep
    Khunnawutmanotham, Nisachon
    Chimnoi, Nitirat
    Jumruksa, Apiwan
    Ruchirawat, Somsak
    Thasana, Nopporn
    TETRAHEDRON, 2014, 70 (43) : 8017 - 8022
  • [26] Three lycopodium alkaloid N-oxides from Huperzia serrata
    Gao, WY
    Li, YM
    Jiang, SH
    Zhu, DY
    PLANTA MEDICA, 2000, 66 (07) : 664 - 667
  • [27] Two new nitrone alkaloids from Huperzia serrata
    Gao, Wen-Yun
    Li, Yi-Ming
    Jiang, Shan-Hao
    Zhu, Da-Yuan
    HELVETICA CHIMICA ACTA, 2008, 91 (06) : 1031 - 1035
  • [28] Two New Lycopodine Alkaloids from Huperzia serrata
    Jiang, Jinhe
    Liu, Ying
    Min, Kang
    Jing, Bi
    Wang, Liqin
    Zhang, Yan
    Chen, Yegao
    HELVETICA CHIMICA ACTA, 2010, 93 (06) : 1187 - 1191
  • [29] Two Lycopodium alkaloids from the aerial parts of Huperzia phlegmaria
    Dang Kim Thu
    Dao Thi Vui
    Bui Thanh Tung
    PHARMACOGNOSY RESEARCH, 2019, 11 (04): : 396 - 399
  • [30] Huperzine W,a Novel 14 Carbons Lycopodium Alkaloid from Huperzia serrata
    Chang Heng TAN
    ChineseChemicalLetters, 2002, (04) : 331 - 332
12345