Biodegradable Dendronized Polymers for Efficient mRNA Delivery

被引：9
|
作者：
Oldenhuis, Nathan J. [1 ]
Eldredge, Alexander C. [1 ]
Burts, Alan O. [1 ]
Ryu, Keun Ah [1 ]
Chung, Jae [1 ]
Johnson, Mark E. [1 ]
Guan, Zhibin [1 ]
机构：
[1] Univ Calif Irvine, Dept Chem, 1102 Nat Sci 2, Irvine, CA 92697 USA
来源：
CHEMISTRYSELECT | 2016年 / 1卷 / 15期
基金：
美国国家卫生研究院;
关键词：
Dendritic Cells; Dendronized Polymers; Gene Delivery; Immune Cells; mRNA Delivery; DENDRITIC CELLS; TRANSFECTION EFFICIENCY; IN-VIVO; EXPRESSION; THERAPY; PSEUDOURIDINE; VACCINATION; SIRNA; MICE;
D O I：
10.1002/slct.201600939
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
As chemically modified messenger RNAs become less immunogenic and more stable against RNases, the need for synthetic vectors that can efficiently deliver mRNA into cells has increased significantly. Based on a dendronized polypeptide (denpol) architecture, we describe here the development of a synthetic vector system for efficient delivery of mRNAs. The optimized denpols show high efficiency of mRNA delivery to a variety of cells including primary murine dendritic cells (BMDCs), giving it potential use for anti-tumor immunotherapy.
引用
收藏
页码：4413 / 4417
页数：5
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