Biodegradable Dendronized Polymers for Efficient mRNA Delivery

被引：9
|
作者：
Oldenhuis, Nathan J. [1 ]
Eldredge, Alexander C. [1 ]
Burts, Alan O. [1 ]
Ryu, Keun Ah [1 ]
Chung, Jae [1 ]
Johnson, Mark E. [1 ]
Guan, Zhibin [1 ]
机构：
[1] Univ Calif Irvine, Dept Chem, 1102 Nat Sci 2, Irvine, CA 92697 USA
来源：
CHEMISTRYSELECT | 2016年 / 1卷 / 15期
基金：
美国国家卫生研究院;
关键词：
Dendritic Cells; Dendronized Polymers; Gene Delivery; Immune Cells; mRNA Delivery; DENDRITIC CELLS; TRANSFECTION EFFICIENCY; IN-VIVO; EXPRESSION; THERAPY; PSEUDOURIDINE; VACCINATION; SIRNA; MICE;
D O I：
10.1002/slct.201600939
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
As chemically modified messenger RNAs become less immunogenic and more stable against RNases, the need for synthetic vectors that can efficiently deliver mRNA into cells has increased significantly. Based on a dendronized polypeptide (denpol) architecture, we describe here the development of a synthetic vector system for efficient delivery of mRNAs. The optimized denpols show high efficiency of mRNA delivery to a variety of cells including primary murine dendritic cells (BMDCs), giving it potential use for anti-tumor immunotherapy.
引用
收藏
页码：4413 / 4417
页数：5
相关论文
共 50 条
  • [31] A Versatile Strategy to Transform Cationic Polymers for Efficient and Organ-Selective mRNA Delivery
    Lin, Lixin
    Su, Kexin
    Zhang, Xinyue
    Shi, Lu
    Yan, Xinxin
    Fu, Qiuli
    Yao, Ke
    Siegwart, Daniel J.
    Liu, Shuai
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025,
  • [32] Conformational statistics of dendronized polymers
    Welch, PM
    Welch, CF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U4180 - U4181
  • [33] Rheology and Packing of Dendronized Polymers
    Costanzo, Salvatore
    Scherz, Leon F.
    Schweizer, Thomas
    Kroger, Martin
    Floudas, George
    Schluter, A. Dieter
    Vlassopoulos, Dimitris
    MACROMOLECULES, 2016, 49 (18) : 7054 - 7068
  • [34] Syntheses and applications of dendronized polymers
    Liu, Xiong
    Lin, Wei
    Astruc, Didier
    Gu, Haibin
    PROGRESS IN POLYMER SCIENCE, 2019, 96 : 43 - 105
  • [35] Synthesis and characterization of dendronized polymers
    Calderon, Marcelo
    Martinelli, Marisa
    Froimowicz, Pablo
    Leiva, Angel
    Gargallo, Ligia
    Radic, Deodato
    Strumia, Miriam C.
    MACROMOLECULAR SYMPOSIA, 2007, 258 : 53 - 62
  • [36] Polynsaids: Biodegradable polymers for localized drug delivery.
    Uhrich, KE
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U909 - U909
  • [37] Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration
    Aoki, Kaoru
    Saito, Naoto
    PHARMACEUTICS, 2020, 12 (02)
  • [38] Local drug delivery system using biodegradable polymers
    Gilson Khang
    John M. Rhee
    Je Kyo Jeong
    Jeong Sik Lee
    Moon Suk Kim
    Sun Hang Cho
    Hai Bang Lee
    Macromolecular Research, 2003, 11 : 207 - 223
  • [39] BIODEGRADABLE POLYMERS FOR PROTEIN AND PEPTIDE DRUG-DELIVERY
    GOMBOTZ, WR
    PETTIT, DK
    BIOCONJUGATE CHEMISTRY, 1995, 6 (04) : 332 - 351
  • [40] New biodegradable polymers for injectable drug delivery systems
    Jeong, B
    Choi, YK
    Bae, YH
    Zentner, G
    Kim, SW
    JOURNAL OF CONTROLLED RELEASE, 1999, 62 (1-2) : 109 - 114
12345