Biodegradable Dendronized Polymers for Efficient mRNA Delivery

被引：9

作者：

Oldenhuis, Nathan J. ^{[1
]}

Eldredge, Alexander C. ^{[1
]}

Burts, Alan O. ^{[1
]}

Ryu, Keun Ah ^{[1
]}

Chung, Jae ^{[1
]}

Johnson, Mark E. ^{[1
]}

Guan, Zhibin ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, 1102 Nat Sci 2, Irvine, CA 92697 USA

来源：

CHEMISTRYSELECT | 2016年 / 1卷 / 15期

基金：

美国国家卫生研究院;

关键词：

Dendritic Cells; Dendronized Polymers; Gene Delivery; Immune Cells; mRNA Delivery; DENDRITIC CELLS; TRANSFECTION EFFICIENCY; IN-VIVO; EXPRESSION; THERAPY; PSEUDOURIDINE; VACCINATION; SIRNA; MICE;

D O I：

10.1002/slct.201600939

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As chemically modified messenger RNAs become less immunogenic and more stable against RNases, the need for synthetic vectors that can efficiently deliver mRNA into cells has increased significantly. Based on a dendronized polypeptide (denpol) architecture, we describe here the development of a synthetic vector system for efficient delivery of mRNAs. The optimized denpols show high efficiency of mRNA delivery to a variety of cells including primary murine dendritic cells (BMDCs), giving it potential use for anti-tumor immunotherapy.

引用

页码：4413 / 4417

页数：5

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