Electrochemically promoted C-3 amination of 2H-indazoles

被引：37

作者：

Sun, Mingli ^{[1
,2
,3
]}

Zhou, Yuhui ^{[1
,2
]}

Li, Laiqiang ^{[3
]}

Wang, Lei ^{[1
,2
,3
,4
]}

Ma, Yongmin ^{[1
,2
]}

Li, Pinhua ^{[3
]}

机构：

[1] Taizhou Univ, Adv Res Inst, Taizhou 318000, Zhejiang, Peoples R China

[2] Taizhou Univ, Dept Chem, Taizhou 318000, Zhejiang, Peoples R China

[3] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1039/d0qo01088j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper reports a metal-free and external oxidant-free electrochemical method for the C-3 amination of 2H-indazoles. The protocol employs commercially available azoles and aliphatic amines as amination reagents and has a broad substrate scope, providing the corresponding C3-amination products in high yields at room temperature. Mechanistic studies indicate that an oxidative addition/elimination sequence is involved under electrochemical conditions.

引用

页码：754 / 759

页数：6

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