Electrochemically promoted C-3 amination of 2H-indazoles

被引：37
|
作者：
Sun, Mingli [1 ,2 ,3 ]
Zhou, Yuhui [1 ,2 ]
Li, Laiqiang [3 ]
Wang, Lei [1 ,2 ,3 ,4 ]
Ma, Yongmin [1 ,2 ]
Li, Pinhua [3 ]
机构：
[1] Taizhou Univ, Adv Res Inst, Taizhou 318000, Zhejiang, Peoples R China
[2] Taizhou Univ, Dept Chem, Taizhou 318000, Zhejiang, Peoples R China
[3] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 04期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1039/d0qo01088j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This paper reports a metal-free and external oxidant-free electrochemical method for the C-3 amination of 2H-indazoles. The protocol employs commercially available azoles and aliphatic amines as amination reagents and has a broad substrate scope, providing the corresponding C3-amination products in high yields at room temperature. Mechanistic studies indicate that an oxidative addition/elimination sequence is involved under electrochemical conditions.
引用
收藏
页码：754 / 759
页数：6
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