Iron promoted C3-H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

被引：44

作者：

Murugan, Arumugavel ^{[1
]}

Gorantla, Koteswar Rao ^{[1
]}

Mallik, Bhabani S. ^{[1
]}

Sharada, Duddu S. ^{[1
]}

机构：

[1] Indian Inst Technol Hyderabad, Dept Chem, Sangareddy 502285, Telangana, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 28期

关键词：

C-H FUNCTIONALIZATION; CATALYZED REMOTE C; BOND ACTIVATION; THERMAL-DECOMPOSITION; NITROGEN-HETEROCYCLES; RADICAL NITRATION; ORGANIC-SYNTHESIS; ALKALOID ANALOGS; HYBRID MOLECULES; DERIVATIVES;

D O I：

10.1039/c8ob00931g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient C3-H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C-H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.

引用

页码：5113 / 5118

页数：6

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