Synthesis of enantiomerically pure pyrrolidinones as endothelin receptor antagonists

被引：15

作者：

Bhagwat, SS ^{[1
]}

Gude, C ^{[1
]}

Chan, K ^{[1
]}

机构：

[1] CIBA GEIGY CORP,DIV PHARMACEUT,RES DEPT,SUMMIT,NJ 07901

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 27期

关键词：

D O I：

10.1016/0040-4039(96)00919-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically pure pyrrolidinones were synthesized as endothelin receptor antagonists. A [2+2] cycloaddition of an imine and an enantiomerically pure acid chloride gave two diastereomeric beta-lactams which were separated and rearranged to give the enantiomerically pure pyrrolidinones which could be reduced to give the corresponding pyrrolidines. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：4627 / 4630

页数：4

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