Synthesis of enantiomerically pure pyrrolidinones as endothelin receptor antagonists

被引：15
|
作者：
Bhagwat, SS [1 ]
Gude, C [1 ]
Chan, K [1 ]
机构：
[1] CIBA GEIGY CORP,DIV PHARMACEUT,RES DEPT,SUMMIT,NJ 07901
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 27期
关键词：
D O I：
10.1016/0040-4039(96)00919-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enantiomerically pure pyrrolidinones were synthesized as endothelin receptor antagonists. A [2+2] cycloaddition of an imine and an enantiomerically pure acid chloride gave two diastereomeric beta-lactams which were separated and rearranged to give the enantiomerically pure pyrrolidinones which could be reduced to give the corresponding pyrrolidines. Copyright (C) 1996 Elsevier Science Ltd
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收藏
页码：4627 / 4630
页数：4
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