Structure and sequence of the mouse V1a and V1b vasopressin receptor genes

被引：12
|
作者：
Kikuchi, S
Tanoue, A
Goda, N
Matsuo, N
Tsujimoto, G
机构：
[1] Natl Childrens Med Res Ctr, Dept Mol Cell Pharmacol, Setagaya Ku, Tokyo 1548509, Japan
[2] Keio Univ, Sch Med, Dept Pediat, Shinjuku Ku, Tokyo 1608582, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1999年 / 81卷 / 04期
关键词：
V1a vasopressin receptor gene (mouse); V1b vasopressin receptor gene (mouse);
D O I：
10.1254/jjp.81.388
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse Via receptor gene was located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two coding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectively, located before the respective seventh transmembrane domain of the receptor sequence. The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice.
引用
收藏
页码：388 / 392
页数：5
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