Structure and sequence of the mouse V1a and V1b vasopressin receptor genes

被引：12
|
作者：
Kikuchi, S
Tanoue, A
Goda, N
Matsuo, N
Tsujimoto, G
机构：
[1] Natl Childrens Med Res Ctr, Dept Mol Cell Pharmacol, Setagaya Ku, Tokyo 1548509, Japan
[2] Keio Univ, Sch Med, Dept Pediat, Shinjuku Ku, Tokyo 1608582, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1999年 / 81卷 / 04期
关键词：
V1a vasopressin receptor gene (mouse); V1b vasopressin receptor gene (mouse);
D O I：
10.1254/jjp.81.388
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse Via receptor gene was located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two coding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectively, located before the respective seventh transmembrane domain of the receptor sequence. The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice.
引用
收藏
页码：388 / 392
页数：5
相关论文
共 50 条
  • [21] Insulin hypersensitivity in mice lacking the V1b vasopressin receptor
    Fujiwara, Yoko
    Hiroyama, Masami
    Sanbe, Atsushi
    Aoyagi, Toshinori
    Birumachi, Jun-ichi
    Yamauchi, Junji
    Tsujimoto, Gozoh
    Tanoue, Akito
    JOURNAL OF PHYSIOLOGY-LONDON, 2007, 584 (01): : 235 - 244
  • [22] Central vasopressin V1a and V1b receptors modulate the cardiovascular response to air-jet stress in conscious rats
    Stojicic, Sonja
    Milutinovic, Sanja
    Sarenac, Olivera
    Zivkovic, Slavoljub
    Japundzic-Zigon, Nina
    BIOMEDIZINISCHE TECHNIK, 2006, 51 (04): : 268 - 271
  • [23] CHED 227-Comparison of structure: Function relationships in the membrane activity of piscicocins V1a and V1b
    Lillig, Jennifer Whiles
    Laird, Daniel
    Mulvihill, Melinda
    Ochsner, Jennifer
    Fry, Nicole
    Crouse, Brandon
    McAlpin, Patrick
    Morgan, Terry
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [24] Molecular modeling of vasopressin receptor and in silico screening of V1b receptor antagonists
    Hagiwara, Yohsuke
    Ohno, Kazuki
    Kamohara, Masazumi
    Takasaki, Jun
    Watanabe, Toshihiro
    Fukunishi, Yoshifumi
    Nakamura, Haruki
    Orita, Masaya
    EXPERT OPINION ON DRUG DISCOVERY, 2013, 8 (08) : 951 - 964
  • [25] Characterization of a functional V1B vasopressin receptor in the male rat kidne evidence for cross talk between V1B and V2 receptor signaling pathways
    Hus-Citharel, Annette
    Bouby, Nadine
    Corbani, Maithe
    Mion, Julie
    Mendre, Christiane
    Darusi, Judit
    Tomboly, Csaba
    Trueba, Miguel
    Serradeil-Le Gal, Claudine
    Llorens-Cortes, Catherine
    Guillon, Gilles
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021, 321 (03) : F305 - F321
  • [26] Glucocorticoids increase vasopressin V1b receptor coupling to phospholipase C
    Rabadan-Diehl, C
    Aguilera, G
    ENDOCRINOLOGY, 1998, 139 (07) : 3220 - 3226
  • [27] Homologous and heterologous phosphorylation of the vasopressin V1a receptor
    Ancellin, N
    Preisser, L
    Le Maout, S
    Barbado, M
    Creminon, C
    Corman, B
    Morel, A
    CELLULAR SIGNALLING, 1999, 11 (10) : 743 - 751
  • [28] Structural determinants in V1a vasopressin receptor function
    Hawtin, SR
    Wheatley, M
    PEPTIDERGIC G PROTEIN-COUPLED RECEPTORS: FROM BASIC RESEARCH TO CLINICAL APPLICATIONS, 1999, 307 : 137 - 143
  • [29] Involvement of vasopressin V1a receptor in the barorellex arc
    Oikawa, Ryo
    Nasa, Yoshihisa
    Ishii, Rie
    Kuwaki, Tomoyuki
    Tanoue, Akito
    Tsujimoto, Gozoh
    Takeo, Satoshi
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2006, 41 (06) : 1071 - 1072
  • [30] Evidence that atypical vasopressin V2 receptor in inner medulla of kidney is V1B receptor
    Saito, M
    Tahara, A
    Sugimoto, T
    Abe, K
    Furuichi, K
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 401 (03) : 289 - 296
12345