Structure and sequence of the mouse V1a and V1b vasopressin receptor genes

被引：12
|
作者：
Kikuchi, S
Tanoue, A
Goda, N
Matsuo, N
Tsujimoto, G
机构：
[1] Natl Childrens Med Res Ctr, Dept Mol Cell Pharmacol, Setagaya Ku, Tokyo 1548509, Japan
[2] Keio Univ, Sch Med, Dept Pediat, Shinjuku Ku, Tokyo 1608582, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1999年 / 81卷 / 04期
关键词：
V1a vasopressin receptor gene (mouse); V1b vasopressin receptor gene (mouse);
D O I：
10.1254/jjp.81.388
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse Via receptor gene was located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two coding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectively, located before the respective seventh transmembrane domain of the receptor sequence. The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice.
引用
收藏
页码：388 / 392
页数：5
相关论文
共 50 条
  • [31] CRITICAL ROLES OF V1A AND V1B VASOPRESSIN RECEPTORS IN SYSTEMIC BLOOD PRESSURE HOMEOSTASIS: STUDIES FROM GENE KNOCKOUT MICE
    Koshimizu, Taka-aki
    Tanoue, Akito
    Nasa, Yoshihisa
    Tsuchiya, Hiroyoshi
    Takeo, Satoshi
    Tsujimoto, Gozoh
    JOURNAL OF VASCULAR RESEARCH, 2009, 46 : 109 - 109
  • [32] Biological characterization of rodent and human vasopressin V1b receptors using SSR-149415, a nonpeptide V1b receptor ligand
    Serradeil-Le Gal, Claudine
    Raufaste, Daniele
    Derick, Sylvain
    Blankenstein, Joerg
    Allen, John
    Pouzet, Brigitte
    Pascal, Marc
    Wagnon, Jean
    Ventura, Maria Angeles
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 293 (02) : R938 - R949
  • [33] Vasopressin V1a, but not V1b, receptors within the PVN of lactating rats mediate maternal care and anxiety-related behaviour
    Bayerl, Doris S.
    Hoenig, Jennifer N.
    Bosch, Oliver J.
    BEHAVIOURAL BRAIN RESEARCH, 2016, 305 : 18 - 22
  • [34] New Topics in Vasopressin Receptors and Approach to Novel Drugs: Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects
    Honda, Kenji
    Takano, Yukio
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 (01) : 38 - 43
  • [35] Conivaptan:: A dual receptor vasopressin V1a/V2 antagonist
    Ali, Farhan
    Raufi, M. Adnan
    Washington, Barbara
    Ghali, Jalal K.
    CARDIOVASCULAR DRUG REVIEWS, 2007, 25 (03): : 261 - 279
  • [36] Beneficial antidiabetic actions of a novel V1a and V1b receptor specific AVP analogue in high fat fed mice
    Moffett, C. R.
    Mohan, S.
    Irwin, N.
    Flatt, P. R.
    DIABETOLOGIA, 2021, 64 (SUPPL 1) : 241 - 241
  • [37] Regulation of vasopressin V1b receptors and stress adaptation
    Volpi, S
    Rabadán-Diehl, C
    Aguilera, G
    STRESS: CURRENT NEUROENDOCRINE AND GENETIC APPROACHES, 2004, 1018 : 293 - 301
  • [38] Altered lipid metabolism in vasopressin V1B receptor-deficient mice
    Hiroyama, Masami
    Fujiwara, Yoko
    Nakamura, Kazuaki
    Aoyagi, Toshinori
    Mizutani, Reiko
    Sanbe, Atsushi
    Tasaki, Ryuji
    Tanoue, Akito
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 602 (2-3) : 455 - 461
  • [39] Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
    Wersinger, SR
    Ginns, EI
    O'Carrol, AM
    Lolait, SJ
    Young, WS
    MOLECULAR PSYCHIATRY, 2002, 7 (09) : 975 - 984
  • [40] Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
    S R Wersinger
    E I Ginns
    A-M O'Carroll
    S J Lolait
    W S Young III
    Molecular Psychiatry, 2002, 7 : 975 - 984
12345