Anti-inflammatory properties of quebecol and its derivatives

被引：27

作者：

Cardinal, Sebastien ^{[1
,2
]}

Azelmat, Jabrane ^{[3
]}

Grenier, Daniel ^{[3
]}

Voyer, Normand ^{[1
,2
]}

机构：

[1] Univ Laval, Dept Chim, Quebec City, PQ G1V 0A6, Canada

[2] Univ Laval, PROTEO, Quebec City, PQ G1V 0A6, Canada

[3] Univ Laval, Fac Med Dent, Grp Rech Ecol Buccale, Quebec City, PQ G1V 0A6, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Quebecol; Anti-inflammatory activity; Natural polyphenol; Inhibition of NF-kappa B activation; Inhibition of cytokine secretion; MAPLE SYRUP EXTRACT; INFLAMMATION; ALPHA; INTERLEUKIN-8; MEDIA; CYCLE;

D O I：

10.1016/j.bmcl.2015.11.096

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Herein we report our results on the anti-inflammatory activity of quebecol, a polyphenolic compound discovered in maple syrup. Bioassays demonstrated that quebecol has an anti-inflammatory effect on LPS-induced NF-kappa B activation and inhibits the secretion of two pro-inflammatory cytokines, IL-6 and TNF-alpha. We also prepared and tested precursors of quebecol and its derivatives corresponding to its substructures of interest, with the aim to study the structure-activity relationships. Comparing the results obtained for all tested compounds allowed the identification of the main moiety responsible for the anti-inflammatory activity of quebecol. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：440 / 444

页数：5

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