Anti-inflammatory properties of quebecol and its derivatives

被引：27
|
作者：
Cardinal, Sebastien [1 ,2 ]
Azelmat, Jabrane [3 ]
Grenier, Daniel [3 ]
Voyer, Normand [1 ,2 ]
机构：
[1] Univ Laval, Dept Chim, Quebec City, PQ G1V 0A6, Canada
[2] Univ Laval, PROTEO, Quebec City, PQ G1V 0A6, Canada
[3] Univ Laval, Fac Med Dent, Grp Rech Ecol Buccale, Quebec City, PQ G1V 0A6, Canada
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 02期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Quebecol; Anti-inflammatory activity; Natural polyphenol; Inhibition of NF-kappa B activation; Inhibition of cytokine secretion; MAPLE SYRUP EXTRACT; INFLAMMATION; ALPHA; INTERLEUKIN-8; MEDIA; CYCLE;
D O I：
10.1016/j.bmcl.2015.11.096
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Herein we report our results on the anti-inflammatory activity of quebecol, a polyphenolic compound discovered in maple syrup. Bioassays demonstrated that quebecol has an anti-inflammatory effect on LPS-induced NF-kappa B activation and inhibits the secretion of two pro-inflammatory cytokines, IL-6 and TNF-alpha. We also prepared and tested precursors of quebecol and its derivatives corresponding to its substructures of interest, with the aim to study the structure-activity relationships. Comparing the results obtained for all tested compounds allowed the identification of the main moiety responsible for the anti-inflammatory activity of quebecol. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：440 / 444
页数：5
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