A sensitive fluorescent probe for cysteine and Cu2+ based on 1,8-naphthalimide derivatives and its application in living cells imaging

被引：36
|
作者：
Shen, Ronghua [1 ]
Yang, Jingling [1 ]
Luo, Hong [1 ]
Wang, Bingxiang [1 ]
Jiang, Yuliang [1 ]
机构：
[1] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China
来源：
TETRAHEDRON | 2017年 / 73卷 / 04期
关键词：
1,8-Naphthalimide-based derivatives; Fluorescent probe; Detection limits; Cells imaging; RHODAMINE; COPPER; HOMOCYSTEINE; SENSOR; NAPHTHALIMIDE; FLUOROPHORES; CHEMOSENSORS; INDICATORS; FE3+; AG+;
D O I：
10.1016/j.tet.2016.12.016
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new 1,8-naphthalimide derivative (NAD) was synthesized and employed as a highly sensitive and selective probe for the detection of cysteine (Cys) and Cu2+. The terminal olefin of NAD could react with Cys and resulting in fluorescence quenching, with the adding of Cu2+, the schiff base unit of NAD could coordinate with Cu2+ and lead to a highly selective fluorescence "turn-on" response. The detection limits reached as low as 25 nM for Cys and 11 nM for Cu2+. In addition, the NAD probe can be further applied to cells imaging owing to its photostability and low cytotoxicity. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：373 / 377
页数：5
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