A sensitive fluorescent probe for cysteine and Cu2+ based on 1,8-naphthalimide derivatives and its application in living cells imaging

被引：36

作者：

Shen, Ronghua ^{[1
]}

Yang, Jingling ^{[1
]}

Luo, Hong ^{[1
]}

Wang, Bingxiang ^{[1
]}

Jiang, Yuliang ^{[1
]}

机构：

[1] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China

来源：

TETRAHEDRON | 2017年 / 73卷 / 04期

关键词：

1,8-Naphthalimide-based derivatives; Fluorescent probe; Detection limits; Cells imaging; RHODAMINE; COPPER; HOMOCYSTEINE; SENSOR; NAPHTHALIMIDE; FLUOROPHORES; CHEMOSENSORS; INDICATORS; FE3+; AG+;

D O I：

10.1016/j.tet.2016.12.016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new 1,8-naphthalimide derivative (NAD) was synthesized and employed as a highly sensitive and selective probe for the detection of cysteine (Cys) and Cu2+. The terminal olefin of NAD could react with Cys and resulting in fluorescence quenching, with the adding of Cu2+, the schiff base unit of NAD could coordinate with Cu2+ and lead to a highly selective fluorescence "turn-on" response. The detection limits reached as low as 25 nM for Cys and 11 nM for Cu2+. In addition, the NAD probe can be further applied to cells imaging owing to its photostability and low cytotoxicity. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：373 / 377

页数：5

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