Cobalt-Catalyzed α-Alkylation of Ketones with Primary Alcohols

被引：189

作者：

Zhang, Guoqi ^{[1
,2
]}

Wu, Jing ^{[1
,2
,3
]}

Zeng, Haisu ^{[1
,2
,3
]}

Zhang, Shu ^{[1
,2
]}

Yin, Zhiwei ^{[1
,2
,3
]}

Zheng, Shengping ^{[3
]}

机构：

[1] CUNY, Grad Ctr, Dept Sci, John Jay Coll, New York, NY 10019 USA

[2] CUNY, Grad Ctr, PhD Program Chem, New York, NY 10019 USA

[3] CUNY Hunter Coll, Dept Chem, New York, NY 10065 USA

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 05期

基金：

美国国家科学基金会;

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; MILD REACTION CONDITIONS; ASTERISK-LR COMPLEX; C BOND FORMATION; AROMATIC-AMINES; N-ALKYLATION; SELECTIVE HYDROGENATION; IRIDIUM CATALYSTS; BRANCHED PRODUCTS; PINCER COMPLEXES;

D O I：

10.1021/acs.orglett.7b00106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An ionic cobalt-PNP complex is developed for the efficient alpha-alkylation of ketones with primary alcohols for the first time. A broad range of ketone and alcohol substrates were employed, leading to the isolation of alkylated ketones with yields up to 98%. The method was successfully applied to the greener synthesis of quinoline derivatives while using 2-aminobenzyl alcohol as an alkylating reagent.

引用

页码：1080 / 1083

页数：4

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