Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae)

被引：24
|
作者：
Sung, Ping-Jyun [1 ]
Chen, Yu-Pei
Hwang, Tsong-Long
Hu, Wan-Ping
Fang, Lee-Shing
Wu, Yang-Chang
Li, Jan-Jung
Sheu, Jyh-Horng
机构：
[1] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan
[2] Natl Dong Hwa Univ, Inst Marine Biotechnol, Pingtung 944, Taiwan
[3] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[4] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan 333, Taiwan
[5] Kaohsiung Med Univ, Fac Biotechnol, Kaohsiung 807, Taiwan
[6] Natl Dong Hwa Univ, Inst Marine Biodivers & Evolut, Pingtung 944, Taiwan
[7] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
来源：
TETRAHEDRON | 2006年 / 62卷 / 24期
关键词：
briarane; briaexcavatin; Briareum excavatum; octocoral; cytotoxicity; human neutrophil elastase;
D O I：
10.1016/j.tet.2006.03.086
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new briarane-related diterpenoids, designated as briaexcavatins C-F (1-4), were isolated from the Formosan octocoral Briareum excavatum, collected off southern Taiwan coast. The structures of these new metabolites were elucidated by the interpretation of spectroscopic and chemical methods. The configuration of I was further supported by molecular mechanics calculations. Briarane 1 has been shown to exhibit mild cytotoxicity toward MDA-MB-231 human breast tumor cells and briarane 3 was found to show activity to inhibit neutrophil elastase release in humans. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5686 / 5691
页数：6
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