Briarane-Related Diterpenoids from Octocoral Briareum stechei

被引：1
|
作者：
Huynh, Thanh-Hao [1 ,2 ]
Neoh, Choo-Aun [3 ]
Tsai, Yu-Chi [2 ]
Yao, Zhi-Kang [1 ,4 ]
Zheng, Li-Guo [2 ]
Huang, Pin-Chang [2 ]
Wen, Zhi-Hong [1 ,5 ]
Chen, Jih-Jung [6 ]
Wu, Yu-Jen [7 ]
Sung, Ping-Jyun [1 ,2 ,8 ,9 ,10 ]
机构：
[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804201, Taiwan
[2] Natl Museum Marine Biol & Aquarium, Pingtung 944401, Taiwan
[3] Pingtung Christian Hosp, Dept Res, Pingtung 900026, Taiwan
[4] Kaohsiung Vet Gen Hosp, Dept Orthoped, Kaohsiung 813414, Taiwan
[5] Natl Sun Yat Sen Univ, Inst BioPharmaceut Sci, Kaohsiung 804201, Taiwan
[6] Natl Yang Ming Chiao Tung Univ, Sch Pharmaceut Sci, Dept Pharm, Taipei 112304, Taiwan
[7] Meiho Univ, Dept Food Sci & Nutr, Pingtung 912009, Taiwan
[8] China Med Univ, Chinese Med Res & Dev Ctr, Taichung 404332, Taiwan
[9] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807378, Taiwan
[10] Fu Jen Catholic Univ, PhD Program Pharmaceut Biotechnol, New Taipei 242062, Taiwan
来源：
MOLECULES | 2021年 / 26卷 / 22期
关键词：
Briareum stechei; briarane; briaexcavatolie; briastecholide; iNOS; NATURAL-PRODUCTS; SOFT CORALS; DIVERSITY; TAIWAN;
D O I：
10.3390/molecules26226861
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1-4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.
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页数：10
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