Briarenol B, a New Polyoxygenated Briarane from the Octocoral Briareum excavatum

被引：0

作者：

Li, Mu-Jang ^{[1
]}

Su, Yin-Di ^{[2
]}

Liao, Zuo-Jian ^{[2
,3
,4
]}

Wen, Zhi-Hong ^{[3
,4
,5
]}

Su, Jui-Hsin ^{[2
,6
]}

Wu, Yang-Chang ^{[7
,8
,9
,10
]}

Sung, Ping-Jyun ^{[2
,5
,6
,8
,10
]}

机构：

[1] Antai Med Care Corp, Antai Tian Sheng Mem Hosp, Pingtung 928, Taiwan

[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[3] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 804, Taiwan

[4] Acad Sinica, Kaohsiung 804, Taiwan

[5] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[6] Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 944, Taiwan

[7] China Med Univ, Sch Pharm, Coll Pharm, Taichung 404, Taiwan

[8] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

[9] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

[10] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2017年 / 12卷 / 02期

关键词：

Briareum excavation; Octocoral; Briarane; Briarenol; COX-2; iNOS; SOFT CORAL; DITERPENOIDS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new polyoxygenated briarane diterpenoid, briarenol B (1), was isolated from the octocoral Briareum excavatum and its structure determined from spectroscopic data. In RAW264.7 cells, a macrophage-like murine cell line, briarane B (1) was found to enhance the protein expression of pro-inflammatory cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) in cells stimulated by lipopolysaccharide (LPS).

引用

页码：221 / 224

页数：4

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