Briarenols C-E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum

被引：12

作者：

Chen, Nan-Fu ^{[1
,2
]}

Su, Yin-Di ^{[3
]}

Hwang, Tsong-Long ^{[4
,5
,6
,7
,8
]}

Liao, Zuo-Jian ^{[3
,9
,10
]}

Tsui, Kuan-Hao ^{[11
,12
,13
,14
,15
,16
]}

Wen, Zhi-Hong ^{[9
,10
,17
]}

Wu, Yang-Chang ^{[18
,19
,20
]}

Sung, Ping-Jyun ^{[3
,17
,18
,21
,22
]}

机构：

[1] Kaohsiung Armed Forces Gen Hosp, Div Neurosurg, Dept Surg, Kaohsiung 802, Taiwan

[2] Tri Serv Gen Hosp, Dept Neurol Surg, Natl Def Med Ctr, Taipei 114, Taiwan

[3] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[4] Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan 333, Taiwan

[5] Chang Gung Univ, Chinese Herbal Med Res Team, Hlth Aging Res Ctr, Taoyuan 333, Taiwan

[6] Chang Gung Univ Sci & Technol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med, Taoyuan 333, Taiwan

[7] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Coll Human Ecol, Taoyuan 333, Taiwan

[8] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 333, Taiwan

[9] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 804, Taiwan

[10] Acad Sinica, Kaohsiung 804, Taiwan

[11] Kaohsiung Vet Gen Hosp, Dept Obstet & Gynecol, Kaohsiung 813, Taiwan

[12] Natl Yang Ming Univ, Dept Obstet & Gynecol, Taipei 112, Taiwan

[13] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[14] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 804, Taiwan

[15] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan

[16] Tajen Univ, Master Program, Coll Pharm & Hlth Care, Pingtung 907, Taiwan

[17] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[18] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[19] Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 807, Taiwan

[20] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807, Taiwan

[21] Natl Dong Hwa Univ, Inst Marine Biol, Pingtung 944, Taiwan

[22] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

来源：

MOLECULES | 2017年 / 22卷 / 03期

关键词：

Briareum excavatum; octocoral; briarane; briarenol; anti-inflammatory; elastase; iNOS; INHIBITS SUPEROXIDE-PRODUCTION; SOFT CORAL; HUMAN NEUTROPHILS; DITERPENOIDS;

D O I：

10.3390/molecules22030475

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new polyoxygenated briarane diterpenoids, briarenols C-E (1-3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC50 value of 4.65 M. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).

引用

页数：9

共 50 条

[1] Excavatoids A-D, new polyoxygenated briaranes from the octocoral Briareum excavatum
Sung, Ping-Jyun
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Chiang, Michael Y.
Lin, Mei-Ru
Huang, I-Chu
Li, Jan-Jung
Fang, Lee-Shing
Wang, Wei-Hsien
[J]. TETRAHEDRON, 2009, 65 (34) : 6918 - 6924
[2] Briarenols O and P: Novel briaranes from a cultured octocoral Briareum excavatum (Briareidae)
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Yang, San-Nan
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Wen, Zhi-Hong
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[J]. PHYTOCHEMISTRY LETTERS, 2021, 41 : 134 - 138
[3] Briarenols F-H: New polyoxygenated briarane diterpenoids produced by the octocoral Briareum excavatum
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[J]. TETRAHEDRON LETTERS, 2020, 61 (18)
[4] Briacavatolides A-C, New Briaranes from the Taiwanese Octocoral Briareum excavatum
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[J]. MARINE DRUGS, 2012, 10 (05): : 1019 - 1026
[5] New polyoxygenated briaranes from octocorals briareum excavatum and ellisella robusta
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[6] New Polyoxygenated Briaranes from Octocorals Briareum excavatum and Ellisella robusta
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[7] Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum
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[8] Briarenols W-Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral Briareum stechei (Kukenthal, 1908)
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[9] Briarenol B, a New Polyoxygenated Briarane from the Octocoral Briareum excavatum
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[10] Briaexcavatins G and H, two new briaranes from the octocoral Briareum excavatum
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[J]. Bulletin of the Chemical Society of Japan, 2006, 79 (12): : 1900 - 1905

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