Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae)

被引：24

作者：

Sung, Ping-Jyun ^{[1
]}

Chen, Yu-Pei

Hwang, Tsong-Long

Hu, Wan-Ping

Fang, Lee-Shing

Wu, Yang-Chang

Li, Jan-Jung

Sheu, Jyh-Horng

机构：

[1] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[2] Natl Dong Hwa Univ, Inst Marine Biotechnol, Pingtung 944, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[4] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan 333, Taiwan

[5] Kaohsiung Med Univ, Fac Biotechnol, Kaohsiung 807, Taiwan

[6] Natl Dong Hwa Univ, Inst Marine Biodivers & Evolut, Pingtung 944, Taiwan

[7] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

TETRAHEDRON | 2006年 / 62卷 / 24期

关键词：

briarane; briaexcavatin; Briareum excavatum; octocoral; cytotoxicity; human neutrophil elastase;

D O I：

10.1016/j.tet.2006.03.086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new briarane-related diterpenoids, designated as briaexcavatins C-F (1-4), were isolated from the Formosan octocoral Briareum excavatum, collected off southern Taiwan coast. The structures of these new metabolites were elucidated by the interpretation of spectroscopic and chemical methods. The configuration of I was further supported by molecular mechanics calculations. Briarane 1 has been shown to exhibit mild cytotoxicity toward MDA-MB-231 human breast tumor cells and briarane 3 was found to show activity to inhibit neutrophil elastase release in humans. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5686 / 5691

页数：6

共 38 条

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MOLECULES, 2017, 22 (03)
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