First direct lithiation of 2-pyridylpiperazine on solid phase

被引：19

作者：

Gros, P ^{[1
]}

Louërat, F ^{[1
]}

Fort, Y ^{[1
]}

机构：

[1] Univ Nancy 1, Fac Sci, UMR CNRS UHP 7565, F-54506 Vandoeuvre Les Nancy, France

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 10期

关键词：

D O I：

10.1021/ol025826f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The first direct lithiation of a pyridine derivative on solid phase has been realized. Metalation of polymer-bound 2-pyridylpiperazine with the BuLi-LiDMAE reagent followed by electrophilic quenching and subsequent cleavage provided a range of new useful C-6 substituted 2-piperazinylpyridines.

引用

页码：1759 / 1761

页数：3

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