First direct lithiation of 2-pyridylpiperazine on solid phase

被引：19
|
作者：
Gros, P [1 ]
Louërat, F [1 ]
Fort, Y [1 ]
机构：
[1] Univ Nancy 1, Fac Sci, UMR CNRS UHP 7565, F-54506 Vandoeuvre Les Nancy, France
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 10期
关键词：
D O I：
10.1021/ol025826f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The first direct lithiation of a pyridine derivative on solid phase has been realized. Metalation of polymer-bound 2-pyridylpiperazine with the BuLi-LiDMAE reagent followed by electrophilic quenching and subsequent cleavage provided a range of new useful C-6 substituted 2-piperazinylpyridines.
引用
收藏
页码：1759 / 1761
页数：3
相关论文
共 50 条
  • [31] First principles calculations of solid phase transition of nitromethane
    Zhang Li
    Chen Lang
    ACTA PHYSICA SINICA, 2014, 63 (09)
  • [32] The first solid phase synthesis of pincer palladium complexes
    Kozlov, Vladimir A.
    Aleksanyan, Diana V.
    Korobov, Mikhail V.
    Avramenko, Natalya V.
    Aysin, Rinat R.
    Maloshitskaya, Olga A.
    Korlyukov, Alexander S.
    Odinets, Irina L.
    DALTON TRANSACTIONS, 2011, 40 (35) : 8768 - 8772
  • [33] First-principles assessment of chemical lithiation of sulfide solid electrolytes and its impact on their transport, electronic and mechanical properties
    Hao, Wei
    Lee, Myungsuk
    Hwang, Gyeong S.
    JOURNAL OF POWER SOURCES, 2023, 560
  • [34] DIRECT LITHIATION OF BICYCLO[3,2,1]OCTA-2,6-DIENE
    KOHLER, FH
    HERTKORN, N
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1983, 38 (03): : 407 - 408
  • [35] A DIRECT COMPARISON OF FIRST AND 2ND GAS-PHASE BASICITIES OF THE OCTAPEPTIDE RPPGFSPF
    KALTASHOV, IA
    FENSELAU, CC
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (39) : 9906 - 9910
  • [36] DIRECT SOLID-PHASE CHEMILUMINESCENCE IMMUNOASSAY FOR SALIVARY PROGESTERONE
    DEBOEVER, J
    KOHEN, F
    VANDEKERCKHOVE, D
    CLINICAL CHEMISTRY, 1986, 32 (05) : 763 - 767
  • [37] Efficient and direct solid phase synthesis of ketomethylenimino and ketomethylenamino peptides
    Bernard, E
    Vanderesse, R
    TETRAHEDRON LETTERS, 2004, 45 (47) : 8603 - 8606
  • [38] Monitoring of the drying process by direct solid-phase microextraction
    Besse, J
    Fornage, A
    Luisier, JL
    N'Zébo, H
    CHIMIA, 2001, 55 (09) : 741 - 743
  • [39] Direct Solid Phase Microextraction for the Determination of BTEX in Water and Wastewater
    Labaqua S.A. C/ Alona, 33 03007 Alicante, Spain
    不详
    HRC J. High Resol. Chromatogr., 8 (472-474):
  • [40] DIRECT SOLID-PHASE SEQUENCING OF PCR AMPLIFIED DNA
    不详
    FASEB JOURNAL, 1993, 7 (07): : A1312 - A1312
12345