First direct lithiation of 2-pyridylpiperazine on solid phase

被引：19
|
作者：
Gros, P [1 ]
Louërat, F [1 ]
Fort, Y [1 ]
机构：
[1] Univ Nancy 1, Fac Sci, UMR CNRS UHP 7565, F-54506 Vandoeuvre Les Nancy, France
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 10期
关键词：
D O I：
10.1021/ol025826f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The first direct lithiation of a pyridine derivative on solid phase has been realized. Metalation of polymer-bound 2-pyridylpiperazine with the BuLi-LiDMAE reagent followed by electrophilic quenching and subsequent cleavage provided a range of new useful C-6 substituted 2-piperazinylpyridines.
引用
收藏
页码：1759 / 1761
页数：3
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