Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargylic Esters with β-Keto Acids

被引：51
|
作者：
Zhu, Fu-Lin [1 ,2 ]
Wang, Ya-Hui [1 ]
Zhang, De-Yang [1 ,2 ]
Hu, Xin-Hu [1 ]
Chen, Song [1 ]
Hou, Chuan-Jin [1 ,3 ]
Xu, Jie [1 ]
Hu, Xiang-Ping [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Dalian Polytech Univ, Dalian 116034, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 14-15期
关键词：
asymmetric catalysis; copper; decarboxylative propargylic alkylation; beta-keto acids; propargylic esters; CONJUGATE ADDITION; SUBSTITUTION-REACTIONS; 3-HYDROXY OXINDOLES; TERMINAL ALKYNES; MANNICH REACTION; KETOACIDS; ACETATES; AMINATION; ALCOHOLS; AMINES;
D O I：
10.1002/adsc.201400218
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The first copper-catalyzed intermolecular enantioselective decarboxylative propargylic alkylation of propargylic esters with beta-keto acids as surrogates of ketones has been successfully developed by using a ketimine P, N, N-ligand. High yields and excellent enantioselectivities (up to 98% ee) have been achieved under the mild reaction conditions.
引用
收藏
页码：3231 / 3236
页数：6
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