Copper-Catalyzed Enantioselective Propargylic Amination of Nonaromatic Propargylic Esters with Amines

被引：60
|
作者：
Yoshida, Akiko [1 ]
Hattori, Gaku [1 ]
Miyake, Yoshihiro [1 ]
Nishibayashi, Yoshiaki [1 ]
机构：
[1] Univ Tokyo, Sch Engn, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 09期
关键词：
SUBSTITUTION-REACTIONS; ASYMMETRIC HYDROGENATION; ALLENYLIDENE COMPLEXES; REDUCTIVE CYCLIZATION; ALCOHOLS; ALDEHYDES; ACETATES; INDOLES;
D O I：
10.1021/ol200703g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The enantioselective propargylic amination of propargylic pentafluorobenzoates bearing an alkyl group at the propargylic position with amines in the presence of catalytic amounts of a copper complex and an optically active diphosphine such as BINAP has been found to give the corresponding propargylic amines in good yields with high enantioselectivity.
引用
收藏
页码：2460 / 2463
页数：4
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